Board Thread:New on 3-bromopyruvate Wikia/@comment-26400607-20150528164629

For the past few days I have been looking into what routes are used to synthesize 3-BP. [Click below on url and then on view details for further details and journal references.] I have found it interesting thinking about the 5 different routes of synthesis.

Chemical suppliers would likely try the cheapest route, though this would not necessarily be the safest for patients, considering the other products generated during the reaction. Consider the synthesis route that uses water: this generates a contaminant called 3,3 dibromo-2-oxopropanoic acid. It sounds scary.The 1-diazonio one looks interesting. Ethyl-bromopyruvate could be another cancer fighter (It is similar to 3BrOP.).

I have also thought that it would be pretty neat if you could take your 3-BP to a chemical "polisher" that would remove some of the contaminants. It is quite possible that the chemical suppliers do not make any particular effort to remove contaminants. Several methods spring to my mind.

For example: the density of 3-BP is about 2.5. It should sink in water. In some of the reactions, the contaminants have a  density of less than 1. They should float on water. Simply putting the 3-BP mixture and filtering the top layer would help purify it. I have read that a user of 3-BP did just that as there was a yellow substance floating on the top! Other purifications could be done include heating it etc..

http://www.molbase.com/en/synthesis_1113-59-3-moldata-8403.html#tabs

One advantage of going to a recognized cancer clinic for 3-BP would be that they would have worked all this through. They would know which synthesis route was best (though probably not the cheapest) and have polished the 3-BP so unknown contaminants were not floating on top. Their 3-BP might approach pharmaceutical grade. 