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=Anyone used 3bp (3-bromopyruvate)?= View all Alternative Treatments Discussions Post A New Discussion947 Posts | Page(s): Prev 12...79 80 81 82 83 ...9495 Next Genelle
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RE: Anyone used 3bp (3-bromopyruvate)?
by Genelle on Sat May 09, 2015 05:08 PM Quote | ReplyOn May 09, 2015 6:22 PM james-peters wrote: On May 09, 2015 5:06 AM Genelle wrote:

I ate so little I lost 8 lbs in a week How many calories were you eating a day?That is a good question. I would eat breakfast but later I would throw up when I tried to eat lunch. The only thing we can think is my system was very stressed with the fat and meat and the stress caused the glucose to go up. The doctors took me off the Keto diet so now I am just doing low carb and slow carbs. I was not able to eat enough to stop weight loss. Quote | ReplyMore Sharing Services Share Share on email Share on facebook Share on twitterGenelle
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RE: Anyone used 3bp (3-bromopyruvate)?
by Genelle on Sat May 09, 2015 05:12 PM Quote | ReplyOne of my doctors is looking into  Doxycycline to see how we can use it. Quote | ReplyMore Sharing Services Share Share on email Share on facebook Share on twitterkcervantes
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RE: Anyone used 3bp (3-bromopyruvate)?
by kcervantes on Sat May 09, 2015 09:21 PM Quote | ReplyHi Daniel -

My husband has stage 4 metestatic colon cancer. What do you reccommend for colon cancer patients? Chemo has stopped working and his kidneys are becoming threatened. Any info would be greatly appreciated.

Kim Quote | ReplyMore Sharing Services Share Share on email Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterkcervantes
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RE: Anyone used 3bp (3-bromopyruvate)?
by kcervantes on Sat May 09, 2015 10:24 PM Quote | ReplyHello Daniel -

Can you give me the contact info for the chinese supplier?? Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterDanielus
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RE: Anyone used 3bp (3-bromopyruvate)?
by Danielus on Sun May 10, 2015 05:43 AM Quote | Reply<p class="quoteDetails">On May 10, 2015 2:24 AM kcervantes wrote:

Hello Daniel -

Can you give me the contact info for the chinese supplier?? Hi Kcervantes, I am sorry to hear that about your husband. Yet, there are many ways to act in order to stop that. 3BP is one of the major ones that I fully trust as long as the cancer is visible on PET. Increased LDH is also a sign for high potential of 3BP.

I will send you the contact of my chinese supplier on private. Like I always said, if you can I would better buy 3BP from a western supplier in order to be 100% sure on the quality. If you have a friend (or a friend of a friend) that is working at University or that has a small company, they can order it for you at suppliers such as Sigma Aldrich. You can even contact a PhD student at an University (e.g. chemestry or biochem department) that you may not know and ask for help vs additional payment. Since it is about life, I would prefer to be 100% confident on teh quality of 3BP. But if there is no option Chinese source may also be OK.

Regarding options next to 3BP, there are many things to say. I wouldl start with Cimetidine (800mg/day), Modified Citrus Pectin and Nattokinase to stop the spread. To support the organs I would take Astragalus, Silimaryn and Alfa Lipoic Acid (600mg/day). To inhibit angiogenesis you can add Celecobex (400mg/day). Than to attack the cancer cells I would add 8g/day of Curcumin to kill the CSC (like Peter sayd as well). DCA oral form should also be considered (for dose see a previous linke I sent on this thread or check the dca site). Artemisinin is clearly one to consider for colon (but for other cancers as well) while working well with 3BP. While little known, Honokiol is a greta element to add. It has strong anticancer mechanisms behind almost at a same level with Curcumin. The best brand to my knowledge is Honopure.

Omeprazole 40mg/day will also help.

Quercetin is a very good one to add specifically for colon but once you start 3BP stop Quercetin.

There are many things to add but this is a list of supplements that are easy accessible and you can start the administration today.

I hope it helps. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterkcervantes
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RE: Anyone used 3bp (3-bromopyruvate)?
by kcervantes on Sun May 10, 2015 12:04 PM Quote | ReplyDaniel -

Thank you sooo much for your insight! Would a pharmacist be able to order the 3BP? His sister is a pharmacist. Also, what is the reccommended dosage?

Funny, I just bought Cimetidine 2 days ago and started him on it :)  I will add the other items you mentioned asap.  Thank you!! Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 10, 2015 12:59 PM Quote | ReplyIn terms of a protocol for the 3-BP, consider the melanoma patient: Chin J Cancer. 2014 Jul;33(7):356-64. doi: 10.5732/cjc.013.10111. Epub 2014 Mar 14. Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study.It really seems that following a similar approach would make quite a bit of sense. Stay with simply IV 3-BP and paracetamol, though just gradually work up the dose of 3-BP and feel comfortable with the downward trend of LDH. This treatment seems to have more horsepower by itself without having to add much on top.The melanoma patient was ultimately more at risk from the side effects of 3-BP treatment (i.e. TLS) than the cancer itself (The doctors noted that at the last labs, the patient had been metabolically cured of cancer). Additions could always included later on (perhaps fasting (ketogenic), butyrate ...).It is not entirely clear to me whether kidney mets would pose any specific concerns.On this thread, little discussion has been directed at the question of targetting cancer in the GI tract. Oral 3-BP might be one option, though it might be really effective to find some sort of direct delivery method.For example, Pillcam with a therapeutic payload. I have often imagined what the result of a Pillcam, with a theraputic payload (e.g. 3-BP) and a balloon might accomplish. If a balloon (or balloons) could be inflated right around a GI tumor, then the entire tumor could be dosed. A 10 mg dose of 3-BP so applied might simply vaporize a tumor ( A 10 mg dose would be way more than would be needed). Alternatively, a target specific GI target pill might be considered. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 10, 2015 04:45 PM Quote | ReplyWhat is the feeling on the thread regarding whether we should now really be thinking beyond straight 3-BP?

Fro example, Prescience Labs the company preparing to start a 3-BP phase 1 trial recently published a modified version of 3-BP:

Clin Cancer Res. 2014 Dec 15;20(24):6406-17. doi: 10.1158/1078-0432.CCR-14-1271. Epub 2014 Oct 17.

Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer.

As we have noted previously on this thread, the methodology used to make this modified version of 3-BP seemed simple.

Microencapsulation of 3-BrPA and nuclear magnetic resonance spectroscopy"Encapsulation of 3-BrPA in β-CD was achieved by portionwise addition of 3-BrPA (166 mg, 1 mmol/L) to a stirring solution of β-CD (1,836 mg in 30 mL DI water). The resulting solution was sonicated for 1 hour at room temperature and then shaken overnight at 25°C, flash frozen, and lyophilized. Encapsulation was confirmed by1H-NMR experiments performed at 400 MHz on a Bruker Avance spectrometer."

What stir, sonicate, shake, freeze and lyophilize? That does not appear overly complex.

"The main finding of this study is that systemically delivered β-CD–3-BrPA achieved strong antitumoral effects in vivo while causing much less toxicity in therapeutic doses when compared with the free drug."

Staying with the known treatment protocol (3-BP + paractamol) might be the best bet. However, if given carefully, encapsulation could amp up the response.

MD Anderson has developed what they call a third generation glycolysis inhibitor, 3-BrOP (Glycolysin).

http://www.cancercuremedicine.com/news-md-anderson-3-brop-or

3-bromo-2-oxopropionate-1-propyl ester (3-BrOP)

http://www.freepatentsonline.com/y2006/0058383.html

"The inventors show that Glycolycin and its derivatives/analogs have superior pharmaceutical properties compared to other glycolytic inhibitors, and is able to effectively block glycolysis and cause a severe depletion of the cellular ATP pool and massive cell death, especially in cancer cells with increased dependency on glycolysis in a hypoxic environment or when mitochondrial respiration is defective."

Interestingly, page 3 of the pdf below appears to give the chemical method necessary to synthesize 3BrOP.

http://www.freepatentsonline.com/20060058383.pdf

The patent below claims that the reason 3-BP has not went mainstream is the side effects caused by it. Interestingly, it is claimed that:

"Subsequent doses of 2000 mg twice a day of liposomal reduced glutathione are administered daily for 7 days following the administration of 3BP to minimize the effects of tumorlysis debris known as tumorlysis syndrome "

http://www.google.com/patents/US20130177630

Mito-3-BP was very startlingly effective. Chem Sci. 2015 Mar;6(3):1832-1845. The energy blocker inside the power house: Mitochondria targeted delivery of 3-bromopyruvate.Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterjames-peters
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RE: Anyone used 3bp (3-bromopyruvate)?
by james-peters on Sun May 10, 2015 05:23 PM Quote | ReplyGlutamine Addiction: A New Therapeutic Target in Cancer http://www.ncbi.nlm.nih.gov/pubmed/9349841 http://www.ncbi.nlm.nih.gov/pubmed/7954430 http://www.nature.com/cr/journal/v22/n3/full/cr20125a.html http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917518/ Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterjames-peters
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RE: Anyone used 3bp (3-bromopyruvate)?
by james-peters on Sun May 10, 2015 05:24 PM Quote | Reply<p class="quoteDetails">On May 09, 2015 7:24 PM Danielus wrote: <p class="quoteDetails">On May 09, 2015 6:26 PM james-peters wrote:

Oxaloacetate, an intermediate of the Krebs cycle, has been designated an orphan drug by the FDA. 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rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22297683" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22297683 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22297683"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22297683" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22297683 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22297683"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22297683" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22297683 Oxaloacetate seems interesting. Do you have additional relevant info on it? Sadly there isn't much data on it. It seems it reduces glutamine levels in the body and can have an effect on glucose levels too. It may also effect certain pathways as well Quote | Reply

=Anyone used 3bp (3-bromopyruvate)?= View all Alternative Treatments Discussions Post A New Discussion947 Posts | Page(s): Prev 12...80 81 82 83 84 ...9495 Next james-peters
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RE: Anyone used 3bp (3-bromopyruvate)?
by james-peters on Sun May 10, 2015 05:30 PM Quote | ReplyCombining a novel glycolysis inhibitor, 3-BrOP, with the mTOR inhibitor, rapamycin, induced more than 90% cell death in human tissue cultures of acute lymphocytic leukemia http://www.mdanderson.org/newsroom/news-releases/2008/new-dr and http://www.ncbi.nlm.nih.gov/pubmed/21316758

Novel Cancer Drug Reduces Neuroblastoma Growth by 75% http://www.mdanderson.org/newsroom/news-releases/2009/novel- and http://www.ncbi.nlm.nih.gov/pubmed/20890785

Effective Elimination of Cancer Stem Cells By a Novel Drug Combination Strategy http://www.cancercuremedicine.com/uploads/4/3/7/1/43718009/c http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538380/

Results: 5 http://www.ncbi.nlm.nih.gov/pubmed/?term=3-BrOP

According to MD Anderson We already knew that 3-BrOP was effective in preclinical research of glioblastoma, colon cancer and lymphoma & A Phase I clinical trial is planned to open this year for adult patients (this was from 2009). Also it seems its a glycolysis inhibitor. If it is then what about mitochondrial ATP? Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 10, 2015 05:38 PM Quote | Reply"The inventors show that Glycolycin and its derivatives/analogs have superior pharmaceutical properties compared to other glycolytic inhibitors, and is able to effectively block glycolysis and cause a severe depletion of the cellular ATP pool and massive cell death, especially in cancer cells with increased dependency on glycolysis in a hypoxic environment or when mitochondrial respiration is defective."

http://www.freepatentsonline.com/y2006/0058383.html

It is interesting and disappointing that the optimal form of 3-BP does not appear to have yet established. The patent still needs to make broad claims for the best chemical composition. They still do not know!

"An ester of 3-halo-2-oxopropionate may also be 3-bromo-2-oxopropionic acid ethyl ester (which may be referred to herein as E-Glycolycin, also referred to as ethyl 3-bromo-2-oxopropionate or ethyl 3-bromopyruvate); 3-fluoro-2-oxopropionic acid ethyl ester; 3-chloro-2-oxopropionic acid ethyl ester; or 3-iodo-2-oxopropionic acid ethyl ester. An ester of 3-halo-2-oxopropionate may also be 3-bromo-2-oxopropionic acid methyl ester (which may be referred to herein as M-Glycolycin, also referred to as methyl 3-bromo-2-oxopropionate or methyl 3-bromopyruvate); ...." Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 10, 2015 05:42 PM Quote | ReplyCould someone share the SMILES for some of these chemicals? Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterjames-peters
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RE: Anyone used 3bp (3-bromopyruvate)?
by james-peters on Sun May 10, 2015 05:52 PM Quote | Reply<p class="quoteDetails">On May 10, 2015 9:38 PM Jcancom wrote:

"The inventors show that Glycolycin and its derivatives/analogs have superior pharmaceutical properties compared to other glycolytic inhibitors, and is able to effectively block glycolysis and cause a severe depletion of the cellular ATP pool and massive cell death, especially in cancer cells with increased dependency on glycolysis in a hypoxic environment or when mitochondrial respiration is defective."

http://www.freepatentsonline.com/y2006/0058383.html"" target="_blank" rel="nofollow">http://www.freepatentsonline.com/y2006/0058383.html" target="_blank" rel="nofollow">http://www.freepatentsonline.com/y2006/0058383.html

It is interesting and disappointing that the optimal form of 3-BP does not appear to have yet established. The patent still needs to make broad claims for the best chemical composition. They still do not know!

"An ester of 3-halo-2-oxopropionate may also be 3-bromo-2-oxopropionic acid ethyl ester (which may be referred to herein as E-Glycolycin, also referred to as ethyl 3-bromo-2-oxopropionate or ethyl 3-bromopyruvate); 3-fluoro-2-oxopropionic acid ethyl ester; 3-chloro-2-oxopropionic acid ethyl ester; or 3-iodo-2-oxopropionic acid ethyl ester. An ester of 3-halo-2-oxopropionate may also be 3-bromo-2-oxopropionic acid methyl ester (which may be referred to herein as M-Glycolycin, also referred to as methyl 3-bromo-2-oxopropionate or methyl 3-bromopyruvate); ...." Have they shown anything, or are they making claims?. Just 5 results from Pubmed, and no Phase I. I haven't read the patent in full, however cancer gets its energy two ways. They use glycolysis and mitochondrial which both produce ATP and cancer can use glutamine. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterjames-peters
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RE: Anyone used 3bp (3-bromopyruvate)?
by james-peters on Sun May 10, 2015 05:56 PM Quote | ReplyHexokinase II: Cancer’s double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385868/ Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714668/ Cancer as a metabolic disease: implications for novel therapeutics http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941741/ The Pivotal Roles of Mitochondria in Cancer: Warburg and Beyond and Encouraging Prospects for Effective Therapies http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890051/ Dr. Peter Pedersen Explaining the Promise of 3-BP and the Warburg effect http://videocast.nih.gov/summary.asp?live=7542 Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 10, 2015 06:05 PM Quote | ReplyYeah, it is very disappointing. 10 years after going through the patent process and they are still preparing for a phase 1 trial (page 4 below). How could ten years possibly be justified? 3-BrOP likely is a step-up from 3-BP- safer and more effective. Why the delay?

http://www.mdanderson.org/publications/children-s-cancer-hos Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 10, 2015 06:09 PM Quote | ReplyHow could the MD Anderson patent possibly be valid? Hopkins must have tried to sew up every possible chemical combination of 3-BP.

If it went to trial I do not know if a jury would buy the argument that 3-BrOP was sufficiently different from 3-BP to allow the patent. The claimed method of action of 3-BrOP appears to be identical to that of 3-BP. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterGenelle
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RE: Anyone used 3bp (3-bromopyruvate)?
by Genelle on Sun May 10, 2015 06:11 PM Quote | ReplyThey can all fight over it while we are dying. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 10, 2015 06:38 PM Quote | ReplyThe real problem might be that all of these trival variances that result in new patent claims deter companies from starting clinical trials at all. 3-BP likely is not the optimal formulation, 3-BrOP is possibly better, though not optimal. It would be hard to justify investing hundreds of millions of dollars only to be outdone by someone who made a minor modification resulting in a better product. Perhaps granting broader patent rights to all related or similar compounds with a specific therapeutic intent would give companies the protection they need to bring products like 3-BP to market.

We are now 15 years out from the first reports of 3-BP anti-cancer properties! If patent laws have really played a part in such an embarrassment, patent laws should be changed. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterGenelle
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RE: Anyone used 3bp (3-bromopyruvate)?
by Genelle on Sun May 10, 2015 07:00 PM Quote | ReplyYou would think that Germany or Switzerland would come up with something because they ave no FDA but I suppose the patent laws would apply there. Maybe China would do it and do medical tourism. It is easy for doctors here to get DCA but not 3BP. Quote | Reply

=Anyone used 3bp (3-bromopyruvate)?= View all Alternative Treatments Discussions Post A New Discussion947 Posts | Page(s): Prev 12...81 82 83 84 85 ...9495 Next Jcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 10, 2015 07:18 PM Quote | ReplyDCA is a repurposed FDA approved drug, 3-BP is a fungicide. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterkcervantes
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RE: Anyone used 3bp (3-bromopyruvate)?
by kcervantes on Mon May 11, 2015 01:56 PM Quote | ReplyHello - How did the 3BP work to stop the spread of your cancer? Are you in remission? Can you give me some insight? Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Mon May 11, 2015 07:17 PM Quote | ReplyTrying to help cancer patients any way I can.

Many members of this thread have been impressed with the results I have posted for minicells.

Curr Opin Biotechnol. 2011 Dec;22(6):909-16. doi: 10.1016/j.copbio.2011.04.008. Epub 2011 May 6. Minicells: versatile vectors for targeted drug or si/shRNA cancer therapy.

A refined method of minicell has recently been announced to that might increase their clinical potential.

J Microbiol Biotechnol. 2015 Apr 28;25(4):554-8. Generation of Minicells from an Endotoxin-Free Gram-Positive Strain Corynebacterium glutamicum.

Engeneic has published 2 phase 1 results and 1 interim phase 1 result. Additional trials are in the works. The dosing in these trials has usednanogramsof chemotherapywith encouraging results.

http://www.engeneic.com/

Under American Right To Try Laws a published phase 1 result is required to access such products (along with a willing supplier-- minicells are widely produced). It is reasonable to assume that minicells will have a substantial place in future cancer care, though it might take upwards of ten years for them to work through the clinical trial process.

Minicells allow direct targetting of cancer cells with minimal off target toxicities. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Mon May 11, 2015 11:59 PM Quote | ReplyI am not completely sure, though it appears Dayspring might have updated their 3-BP page.

For example, they explain why they like 3-BP over DCA and 2DOG. From their experience /understanding, they note that 3-BP has minimal to no toxicity. Additional confirmation of 3-BP safety from a clinical setting is always welcome. What dosing route do they use?

http://www.dayspringcancerclinic.com/why-3bp-is-better-than-

They appear to accept all cancer patients for 3-BP treatment. They also have included a brief patient report.

"Starts Dayspring protocol 12/18/15 with 3-bromopyruvate and other IV’s" IV 3-BP?

http://www.dayspringcancerclinic.com/3bp-cases/ Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterGenelle
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RE: Anyone used 3bp (3-bromopyruvate)?
by Genelle on Tue May 12, 2015 11:03 AM Quote | ReplyJcancom, Maybe they will post how their patients are doing. I am starting Mitoq soon. I have a lot of research on it especially from PubMed on how it kills breast cancer. I cannot post the research because I am not good enough to reduce it all to links and this thread has a word limit. It is supposed to go right into the mitochondria. I have a graduation out of town next week and then I will see if my MD has figured a suitable dose of Doxicycline. I have a little research on that re the mito. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterjames-peters
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RE: Anyone used 3bp (3-bromopyruvate)?
by james-peters on Tue May 12, 2015 08:38 PM Quote | Reply<p class="quoteDetails">On May 12, 2015 3:59 AM Jcancom wrote:

I am not completely sure, though it appears Dayspring might have updated their 3-BP page.

For example, they explain why they like 3-BP over DCA and 2DOG. From their experience /understanding, they note that 3-BP has minimal to no toxicity. Additional confirmation of 3-BP safety from a clinical setting is always welcome. What dosing route do they use?

http://www.dayspringcancerclinic.com/why-3bp-is-better-than-dca-or-2dog/"" target="_blank" rel="nofollow">http://www.dayspringcancerclinic.com/why-3bp-is-better-than- target="_blank" rel="nofollow">http://www.dayspringcancerclinic.com/why-3bp-is-better-than-

They appear to accept all cancer patients for 3-BP treatment. They also have included a brief patient report.

"Starts Dayspring protocol 12/18/15 with 3-bromopyruvate and other IV’s" IV 3-BP?

http://www.dayspringcancerclinic.com/3bp-cases/"" target="_blank" rel="nofollow">http://www.dayspringcancerclinic.com/3bp-cases/" target="_blank" rel="nofollow">http://www.dayspringcancerclinic.com/3bp-cases/ 3BrPA will enter a cancer cells via the upregulated monocarboxylic transporters. Once inside the cell it effects HK2 and VDCA, once these are knocked out both sources of ATP (energy) are gone and the cell dies. It would be nice for Dayspring to upload full PDF case reports and add scans and blood work, along with treatments before, during and after. Also all cases should be reported Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Tue May 12, 2015 09:23 PM Quote | ReplyExactly. Dayspring seemed to go out of their way to provide the minimal possible information in their patient report. Their website noted that a patient started treatment in December 2015 (?)

It is quite possible that there are legal considerations involved. Reporting in detail on patient outcomes might be considered making representations of 3-BP's effectiveness. However, if I were in their position, had 20 to 30 patient reports of mostly positive 3-BP treatments, and it were legal to do so, I would. It would obviously mean everything to  those on this thread and many others, if they did.

There are lingering questions about 3-BP's safety and effectiveness that can only be answered by providing sequential patient reports. Providing such reports would have a significantly positive implication for their revenues. I would expect that a wave of patients would then seek out 3-BP treatment.

It will be very interesting to see what happens once (if?) the phase 1 trial with 3-BP begins. Might the FDA then decide that all IRB authorizations for treatment would be revoked? Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Thu May 14, 2015 07:25 PM Quote | ReplyThis thread is starting to become unwieldy. We have reached almost 830 posts and it is starting to become difficult to find things. Would there be any support by members of this thread to starting a wiki to help consolidate the information contained on this thread into an organized document?

I am not sure where on the net we could go to do this, though there is likely some place. (This forum does not appear to make wiki technology available.)

We could help provide others interested in 3-BP with our collective best assessment and advice. It would also help us from having to repeat some of the jems that can get hidden in all the past posts and it would also allow us to have a fixed knowledge base, as some of the posts on our thread seem to mysteriously disappear from time to time. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterkcervantes
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RE: Anyone used 3bp (3-bromopyruvate)?
by kcervantes on Thu May 14, 2015 07:33 PM Quote | ReplyI think thats a great idea! Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Thu May 14, 2015 08:22 PM Quote | ReplyOK, I have looked into this a little and it appears that setting up a wiki is quite easy.

For example, at

http://www.wikia.com/Special:CreateNewWiki

one can create a free wiki. If others are in, we can begin. Quote | Reply

=Anyone used 3bp (3-bromopyruvate)?= View all Alternative Treatments Discussions Post A New Discussion947 Posts | Page(s): Prev 12...82 83 84 85 86 ...9495 Next Jcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Thu May 14, 2015 08:43 PM Quote | ReplyAlrighty everyone I was like the kid who couldn't wait on Christmas eve to open up his presents.

I have started a new wiki for 3-BP at: http://3bromopyruvate.wikia.com/wiki/3-bromopyruvate_Wikia

I hope others on this thread can help out. I could add some organization to the wiki, and then others might help us fill in the gaps. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Thu May 14, 2015 11:38 PM Quote | ReplyOK everyone, I have built the background for the wiki at the above url.

Help out! Edit in knowledge. The wiki might be a better place for us to communicate as it seems to have the tool set that will help us express ourselves better. For instance, the wiki site allows us to upload images. I am not sure whether we can edit these images though that would be very helpful.

The wiki could be very helpful for us! Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterGenelle
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RE: Anyone used 3bp (3-bromopyruvate)?
by Genelle on Fri May 15, 2015 12:38 AM Quote | ReplyGood idea just let us computer challenged people know how to find it. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Fri May 15, 2015 07:48 AM Quote | Reply[Clickhttp://3bromopyruvate.wikia.com/wiki/3-bromopyruvate_Wikia Clickhttp://3bromopyruvate.wikia.com/wiki/3-bromopyruvate_Wi ]

You will probably need to set up an account to edit the wiki. All they ask is for a username, password, and email address. There might be some sort of restriction at first on editing privileges.

There are quite a few ways that we could develop the wiki. For example, we might upload the entire contents of this thread and index it etc..

Let's see what we can all create together with this wiki! Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterGenelle
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RE: Anyone used 3bp (3-bromopyruvate)?
by Genelle on Fri May 15, 2015 08:02 AM Quote | ReplyI clicked the link but nothing came up Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Fri May 15, 2015 08:05 AM Quote | ReplySorry for some reason the word "click" went into the url.

Try this:

http://3bromopyruvate.wikia.com/wiki/3-bromopyruvate_Wikia Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Fri May 15, 2015 08:35 AM Quote | ReplyClick through on the hyperlinked word Introduction on the first page and then on the hyperlinked word Organization on the second to get to the content. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Fri May 15, 2015 08:58 PM Quote | ReplyThank you! It looks like someone is editing the wiki.

It will be so much easier if we all add a bit. Editing the wiki might not even require a log on. Just hit edit and go. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterKarantu
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RE: Anyone used 3bp (3-bromopyruvate)?
by Karantu on Fri May 15, 2015 09:46 PM Quote | Reply<p class="quoteDetails">On May 16, 2015 12:58 AM Jcancom wrote:

Thank you! It looks like someone is editing the wiki.

It will be so much easier if we all add a bit. Editing the wiki might not even require a log on. Just hit edit and go. Hello Jcancom,

I edited pages a bit but just visual changes. My English is not good enough to do anything further. I also added Table of contents link. Actually I am afraid to make a mistake. Their editor is very basic does not allow multiple undos. I hope you have better management possibilities on pages and menu (as a publisher/starter) and you can undo if I make a mistake. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Fri May 15, 2015 10:03 PM Quote | ReplyThat is great, thank you!

Don't worry about breaking anything. We can always edit back with the previous page archives (I have found this feature helpful on several occasions already).

At some point we might port over this thread to the wiki.There is a lot of great material here, though it has become increasingly difficult to keep it all organized and posts seem to vanish every once and a while.

Once we get started we can get the word out to other forums to help out. Quote | Reply

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RE: Anyone used 3bp (3-bromopyruvate)?
by Genelle on Sat May 16, 2015 12:46 AM Quote | ReplyCan we do private replies? Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sat May 16, 2015 06:38 PM Quote | ReplyEveryone, after ten months investigating 3-BP I have reached the point where I want to take a more activist stance on 3-BP treatment. Scientific investigation can only take us so far.

Ordinarily investigational drugs go through years of clinical trials and eventually a regulatory decision can be made. 3-BP is different. 3-BP already appears to be widely used in cancer centers all over the world.

We need to think of this more as a problem in advocacy and communicating with mass society. Let's think up some ways to move 3-BP treatment forward.

Crowdfunding, a clinical trial for terminal stage cancer patients, political action, protest (Too cool to protest? We could try the rent-a-protest approach!). Maybe we should take our thread on a virtual road trip to different forums all over the world. We could always use internet translators to try and get it right. 3-BP deserves a broader recognition.

We still do not have all the answers, though we have enough. Reasonably, those on this thread who have followed the discussion would agree that if they were put in the position of the liver cancer patient or the metastatic melanoma patient that they would want 3-BP. It seems that we have a moral duty to transmit this information to the millions of terminally ill cancer patients worldwide who face this circumstance every year. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sat May 16, 2015 07:00 PM Quote | ReplyIs there anyone on the thread who wants to launch a Indiegogo Life crowdfunding campaign to get funding for 3-BP? Others on the thread could help out if you wanted to do so.

This could help us get the word out about 3-BP. A thread member with a fairly serious tumor burden and a fair sense of the research knowledge of 3-BP would have considerable online credibility. It would really make others think if someone in such a circumstance would choose 3-BP. Perhaps we could get Dayspring to step up with a discount!

Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sat May 16, 2015 08:34 PM Quote | ReplyMy last post was not clear.

Does anyone on the thread need money for 3-BP treatment?

You could set an Indiegogo Life campaign to raise funds. Such a campaign would raise the awareness of 3-BP for the reasons mentioned in the post. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterGenelle
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RE: Anyone used 3bp (3-bromopyruvate)?
by Genelle on Sun May 17, 2015 01:23 AM Quote | ReplyI am not sure why this person wants to remain anonomous but this is her suggestion.

May I suggest that you and he check out the We Have A Cure Facebook page? Just google that and it will come up. This is written by a female (scientist/doctor?) cannot remember--she herself has had cancer. She, too, is trying to fast track the usage of 3-BP. Her website is mentioned on her Facebook page--cancercuremedicine.com. She has a wealth of information about most everything that has happened with the delay of 3-BP--also the history with Ko and Pedersen. So much to read--I just am not up to it now. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterjames-peters
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RE: Anyone used 3bp (3-bromopyruvate)?
by james-peters on Sun May 17, 2015 01:35 AM Quote | ReplyHere is the facebook page, please 'like' & share https://www.facebook.com/TheCancerCure http://www.cancercuremedicine.com/take-action-now---end-the- Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twittercytoluminator
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RE: Anyone used 3bp (3-bromopyruvate)?
by cytoluminator on Sun May 17, 2015 04:01 AM Quote | Reply<p class="quoteDetails">On Dec 04, 2014 7:49 PM Danielus wrote:

Indeed, that is a very interesting point to discuss: should we expect resistence and if yes what could be the cause for that. Than we can think of drugs that may help to overcome that?

So what could be the reasons for resistence?

I can imagine that one challenge is to reach the tumor location with enough high dose. In that case you may want to coat 3BP with Chitosan to deliver 3BP only to highly acidic environments, i.e. tumor location? http://www.ncbi.nlm.nih.gov/pubmed/18465306"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306

Than there may be limited accees to the tumor. To increase tumor perfusion you may want to use elements such as nitroglycerin: http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378

Than you may want to increase the sensitivity of cancer cells to 3BP. I can imagine that one way of increasing their sensitivity is by reducing glucose (by e.g. restricted ketogenic diet) and reducing glutamine (by e.g. phenyl butyrate). http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475

Use Butyrate pretreatment that may activate MCT expression: http://www.ncbi.nlm.nih.gov/pubmed/22350013"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22350013" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22350013

An extreme case could also be that you want to increaes the amount of transporters MCT by actualy increasing the glucose intake?

Maybe add authophagy inhibitors such as chloroquine? <p data-blkn-colour="rgba(85,85,85,1)">Your guessing is interesting, but our years of experience indicate none of it is accurate. There is no resistance to properly formulated 3BP, but the stuff they are  using in trails is essentially garbage compared to the propriotary formulation we use. There is no need to target it to tumors, and chitosan does not target acidity per se, as soon as it goes into the body it degrades to glucoseamine. We use nano particles when targeting is necessary.

<p data-blkn-colour="rgba(85,85,85,1)">Acetominophene (paracetamol) is not synergistic with 3BP, it is co-active but it does liver damage.

<p data-blkn-colour="rgba(85,85,85,1)">Reducing glucose is not a good idea, it suppresses basal metabolism so the body needs glucose to survive. The whole point of this drug is that it stops the cancer being able to metabolize glucose.

<p data-blkn-colour="rgba(85,85,85,1)">We don't put any sugar restrictions on our patients being treated with our formulation, and we get stunning remissions in days or even hours. However, that is NOT going to happen with 3BP formulations that others use.

<p data-blkn-colour="rgba(85,85,85,1)">If you want to see an example of 3BP that actually works go to http://cancer.cytoluminator.com/brain-cancer.html

<p data-blkn-colour="rgba(85,85,85,1)">and if you want to see the results go to http://cancer.cytoluminator.com/breast-cancer.html and http://cancer.cytoluminator.com/angiosarcoma.html Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterDanielus
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RE: Anyone used 3bp (3-bromopyruvate)?
by Danielus on Sun May 17, 2015 08:18 AM Quote | Reply<p class="quoteDetails">On May 17, 2015 8:01 AM cytoluminator wrote: <p class="quoteDetails">On Dec 04, 2014 7:49 PM Danielus wrote:

Indeed, that is a very interesting point to discuss: should we expect resistence and if yes what could be the cause for that. Than we can think of drugs that may help to overcome that?

So what could be the reasons for resistence?

I can imagine that one challenge is to reach the tumor location with enough high dose. In that case you may want to coat 3BP with Chitosan to deliver 3BP only to highly acidic environments, i.e. tumor location? http://www.ncbi.nlm.nih.gov/pubmed/18465306"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306"" target="_blank" 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rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/18465306 "" target="_blank" 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Than there may be limited accees to the tumor. To increase tumor perfusion you may want to use elements such as nitroglycerin: http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 "" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 " target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 "" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 "" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 " target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 " target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 "" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 " target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 "" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 "" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 " target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 "" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 "" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 " target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 " target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 "" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 " target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 " target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 "" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 " target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 "" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 "" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 " target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 " target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 "" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378 " target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378"" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378" target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01210378

Than you may want to increase the sensitivity of cancer cells to 3BP. I can imagine that one way of increasing their sensitivity is by reducing glucose (by e.g. restricted ketogenic diet) and reducing glutamine (by e.g. phenyl butyrate). http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22932475

Use Butyrate pretreatment that may activate MCT expression: http://www.ncbi.nlm.nih.gov/pubmed/22350013"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22350013" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22350013 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22350013"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22350013" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22350013 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22350013"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22350013" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22350013 "" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22350013"" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22350013" target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/22350013 "" target="_blank" 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An extreme case could also be that you want to increaes the amount of transporters MCT by actualy increasing the glucose intake?

Maybe add authophagy inhibitors such as chloroquine? <p data-blkn-colour="rgba(85,85,85,1)">Your guessing is interesting, but our years of experience indicate none of it is accurate. There is no resistance to properly formulated 3BP, but the stuff they are  using in trails is essentially garbage compared to the propriotary formulation we use. There is no need to target it to tumors, and chitosan does not target acidity per se, as soon as it goes into the body it degrades to glucoseamine. We use nano particles when targeting is necessary.

<p data-blkn-colour="rgba(85,85,85,1)">Acetominophene (paracetamol) is not synergistic with 3BP, it is co-active but it does liver damage.

<p data-blkn-colour="rgba(85,85,85,1)">Reducing glucose is not a good idea, it suppresses basal metabolism so the body needs glucose to survive. The whole point of this drug is that it stops the cancer being able to metabolize glucose.

<p data-blkn-colour="rgba(85,85,85,1)">We don't put any sugar restrictions on our patients being treated with our formulation, and we get stunning remissions in days or even hours. However, that is NOT going to happen with 3BP formulations that others use.

<p data-blkn-colour="rgba(85,85,85,1)">If you want to see an example of 3BP that actually works go to http://cancer.cytoluminator.com/brain-cancer.html"" target="_blank" rel="nofollow">http://cancer.cytoluminator.com/brain-cancer.html" target="_blank" rel="nofollow">http://cancer.cytoluminator.com/brain-cancer.html

<p data-blkn-colour="rgba(85,85,85,1)">and if you want to see the results go to http://cancer.cytoluminator.com/breast-cancer.html"" target="_blank" rel="nofollow">http://cancer.cytoluminator.com/breast-cancer.html" target="_blank" rel="nofollow">http://cancer.cytoluminator.com/breast-cancer.html and http://cancer.cytoluminator.com/angiosarcoma.html"" target="_blank" rel="nofollow">http://cancer.cytoluminator.com/angiosarcoma.html" target="_blank" rel="nofollow">http://cancer.cytoluminator.com/angiosarcoma.html <p class="MsoNormal">To me, what you are doing here looks like pure marketing. I hope you will convince us this is not the case.

<p class="MsoNormal">Just claiming "over 2000 times more powerful" compared to Dr. Ko's formula with no scientific evidence to support that it is at least strange to me. Also, calling garbage the 3BP formulation patented and used so far is not fair. Without that "garbage" you would have no idea on the existence of 3BP. Therefore, could you please share with us convincing evidence to support your claims?

<p class="MsoNormal">You need to do that in order to convince anyone here about your credibility. Nobody would put his life into the hands of somebody making such claims without CONVINCING evidence.

<p class="MsoNormal">Yes, Paracetamol in high dose/long term is known to lead to liver damage - this is what has been already discussed here. But let’s not make something bigger than it is from using Paracetamol. Offcourse you need to use it with care.

<p class="MsoNormal">I am surprised that in contrast to your "years of experience" you do not know that modulating glucose will support glycolysis inhibitors. Furthermore, in case you really have a 3BP formulation stable for 24h at body temperature, I am not sure if I would want to have that circulating in my blood without the glucose restriction. Why? Dr. Ko's patent has the answer: at a time where the subject's blood sugar is low, or the blood insulin/glucagon ratio is low, the normal cells can be protected against any incidental uptake of the anti-cancer active agents. Specifically, such administration can protect the hexokinase 2 (HK-2) enzyme that is present in normal tissues in small amounts. Under low blood sugar conditions, the HK-2 enzyme tends to enter the nucleus of normal cells rather than the cytosolic compartment. The nuclear location of HK-2 provides additional protection against chemo-agents such as 3-bromopyruvate. Reference: https://www.google.com/patents/US8022042 Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterGenelle
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RE: Anyone used 3bp (3-bromopyruvate)?
by Genelle on Sun May 17, 2015 08:44 AM Quote | ReplyI would like to add that you could tell us how to do the treatment ourselves for those people who are not rich you could sell the 3BP with instructions for us to do it at home. After you explain to Daniel the science of how it works, there are a lot of sick people you could help. If we have a good result we will tell the others. The best marketing is word of mouth. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 17, 2015 01:03 PM Quote | ReplyThank you very much for your post!

The Philippines would have an enormous advantage not having to comply with Western style regulatory requirements. Many of the top end doctors have had to migrate out of advanced nations to properly heal their patients. If I were to have the extremely serious cancer burden as shown in the case studies on your website, there would be almost no choice but to go to your clinic or some other clinic with relaxed regulatory oversight.

With current technology there is no reason why cancer has not been cured. In fact, metastatic illness was cured in lab models 20 years ago. With available technology, cancer is no longer an invincible opponent. If I were metastatic cancer, I would be very worried.

It is very interesting that you mentioned nanocells. Your nanocells are 25-30 nm. I thought the 300 nm minicells were found to have an advantage. Have you found a way around the toxicity issues that have been reported with them? Recent research has found that certain strains of minicells have reduced toxicity.

Would be interested to know if you have tried the X-Ray PDT approach. One advantage of that approach is one could target specific body regions to avoid TLS and standard X-Ray equipment could be used. Logically, X-Rays should reach every part of the body, while straight PDT might hve a more limited range.

Has TLS been a problem? The understanding that is developing on this thread and elsewhere is that cancer treatments such as 3-BP already have sufficient cytotoxic power. Giving 2 or 3 doses of 3-BP and paracetamol and curing cancer immediately would not be the safest treatment strategy. One of the real questions that is emerging is how do you gradually reduce tumor burden?

Any information on reformulations of 3-BP would be helpful. Recent research has been reporting on cyclodextrin and Mito-3-BP nanoformulations. Such reformulations would make 3-BP much safer and effective. Are you actually using 3-BP at your clinic? It is somewhat unclear.

Quote | Reply

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RE: Anyone used 3bp (3-bromopyruvate)?
by audiop on Sun May 17, 2015 02:05 PM Quote | ReplyFrom the Cytoluminatorsite:  "We can make you immune to cancer here"My wife was diagnosed 6 years ago with ovarian cancer IIIc. and we've used a combination of standard care chemo, ketogenic diet, HBOT, ketone supplements, etc. to get her to this point. Drs. Seyfried, D'Agostino and others have been very helpful with their personal suggestions and are very accessible.I don't want to sound adversarial but the optics of your company are not very inviting. There is not much information on your site about you… actual address, photos, phone numbers, names etc. Obviously anyone would be suspicious as there are so many companies profiting from the misery of others (you describe "them" on your site).You show miraculous, overnight results so, this in mind, I would assume the short stay at your facility would be relatively inexpensive (you do condemn the huge cost of FDA approved therapies.)So, for example, what might the range of costs be for your ovarian cancer miracle?I just sent you an emailI and will be pleased to give you my phone number when you provide yours. I will provide everyone here with a summary of your email response. Please understand I am a husband trying to give his wife back the life she was supposed to have. I don't have the time or money to deal with snake oil types. I do hope you'll take the opportunity to separate your company from the bad guys.Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 17, 2015 02:32 PM Quote | ReplyI agree with all the concerns raised by those on the thread.

The website is not what a typical Westerner would expect from such a website. From a psychological perspective it is all wrong. Showing graphic images of cancer patients with exposed breasts has been discouraged for decades in the West. Even the arithmetic seems wrong (50 times 200 is not 2000!).

Western medicine has shut out development of 3-BP since its discovery since November 2001. The poster does not appear to be aware that no clinical trials with 3-BP have yet started! The FDA gave authorization almost two years ago.

Even still there is an undeniable logic that prevades the claims being made. If you could give me unrestricted access to a lab, even I without any particular clinical background, could probably produce amazing anti-cancer results. I doubt if knowledgable posters on this thread would even challenge me on this statement. Minicells, X-Ray PDT, third generation 3-BP... cancer should now be easily and safely curable. Metastatic illness was cured in lab models twenty years ago! We cannot afford even more decades for Western medicine to work this through.

The Philippines is likely a place where regulatory oversight would be relaxed. There would be little in the way of legal recourse. In such an environment a cure for cancer could emerge.

Members of this thread would likely agree that a second generation 3-BP formulation (as have already been published in the scientific literature) would be expected to acheive the results posted on the clinic's website. Such a formulation would not only be highly effective: it would also address any lingering safety concerns.

However, I am not quite sure why the website is emphasizing PDT. PDT would not really seem to be the best treatment. I suspect that they really know what they are doing, though I would probably go with their 3-BP formulation.

The site also notes that their patients are not always treatable. This seems surprising as their 3-BP should be able to effectively treat almost all cancer.

It would be helpful if we could contact people who have actually received these treatments. Anyone out there who has received 3-BP from this clinic or elsewhere would be very much welcomed on this thread!

Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 17, 2015 05:02 PM Quote | ReplyMany of the claims on the website seem at least plausible. For example, they claim that they charge only one third what would be charged elsewhere. Most of the American clinics are charging 20 to 30 thousand dollars for treatment with 3-BP. Without ongoing subsequent rounds the cancer would soon return. The liver cancer patient received 10 treatment rounds. Considering the actual cost of 3-BP out competing on price should not be difficult.

If you went to the clinic you would be able to determine within the first day whether they were on the level. A simple LDH test would do it. Even straight 3-BP treatment can move LDH numbers a lot after a single treatment.

It is quite disappointing that the website does not appear to have published case histories. Websites are really not the best forum to communicate medical information. Even if they published in house PDFs with journal format and tone there credibility would be much higher. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 17, 2015 08:52 PM Quote | ReplyDoes anyone know how (if?) we might pull up a one year old archived record of the Cytoluminator site? Would be very interesting to see how their treatment approach has changed over the last year. It seems that they are following the tact we have been discussing of nanocells (minicells) with next generation 3-BP.

It is somewhat surprising that PDT is such a focus with them.However, their website provides a reasonable explanation that PDT is needed for immune activation. Destroying huge numbers of cancer cells with amped up 3-BP should not be mistaken for curing cancer. PDT might push patients over to a cure as their site suggests.

It will be interesting to see whether over the next year they migrate to X-Ray PDT. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitteraudiop
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RE: Anyone used 3bp (3-bromopyruvate)?
by audiop on Mon May 18, 2015 12:25 PM Quote | ReplyI received an email from "Terry" at Cytoluminator.

"Terry" says they've invested $500K in "light sources" and $2M in "medications" and their treatment is 1/3 the cost of everyone else and much more effective.

The price is $35k (or a special deal, $30K if you come through Jessica's Hope). They say they can do a shorter protocol with probably less effectiveness for less cost. I'm in no way making a recommendation but as a comparison, in Phoenix, AZ USA, Dayspring's cost is around $30K. They have an actual facility you can visit before coughing up a lot of dough. Out of country "facilities" like Cytoluminator would do well to initiate Skype conferences so at least you could get an eye to eye impression.

They don't give a phone number because, as "Terry" says, "I don't put my address on the site, if people are not interested enough to talk to me they are probably among the competitors or FDA agents trying to cause trouble for me." Someone please figure that one out as the logic escapes me.

In the case of my wife's ovarian cancer their site says "We have created a new improved formula which last 24 hours so it is much more powerful!  The dose that kills 98% of the cells overnight is below our standard dosage.  We treated an ovarian cancer patient last year, and 24 hours after receiving the medication she tested as no cancer." OK then "Terry"- where's the $1K option for the 98% overnight miracle? Or the $2K option for the two day miracle!

Without real case history or success rates by cancer type, "Terry" is still able to say you "have a 95% chance of complete remission and an immune response that will make it impossible for the cancer to return." By "real case history" I mean not just trotting out your star patients but giving your failures too. In short, actual numbers.

Lacking hundreds of patient endorsements, pictures of real people/main facility, addresses, phone numbers, detailed case studies, stats etc. along with dubious science, I wouldn't go near this company. I've investigated many weird offshore companies for my wife. This is an easy one. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Mon May 18, 2015 02:15 PM Quote | ReplyYeah, it seems disappointing. How did we go from the $50 a night hospital bed mentioned on their website to 35K?

Staying with first world 3-BP clinics would seem to be the easy choice? Why pay more, while losing all the protections afforded by  ... well the FDA, the US legal system etc etc. ?

It should be mentioned that price comparisons could be inexact. 10 treatment stays at an American clinic would cost 300K. Such ongoing treatment would probably be necessary. It was for the liver patient. Perhaps the 35K price was the  cure price.

As well, the patients shown on their website go well beyond the severity of anything published so far. One of their patients had 200 brain mets! At that level of metastatic illness their clinic might be the only one willing to even attempt treatment. In comparison, the patients that we have discussed on this thread had fairly mild illness. It seems that neither the German liver patient nor the Egyptian metastatic melanoma patient had any significant brain mets. For them BP treatment could reasonably offer them a fairly effective treatment.

One thing I am having trouble understanding on their website is the graph showing the effect of 3BP treatment on basal metabolism (measured by temperature). Their figure shows that their special form of 3-BP (X-Gly) reduced temperature by 1.6 for 2 hours. Are they saying that they are reducing the entire body's cellular respiration? Or does the destruction of the cancer only contribute to this effect?

If they were claiming to shut off the body's cellular respiration, then questions of safety would immediately seem to apply. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Mon May 18, 2015 02:38 PM Quote | ReplyOne other thing to keep in mind is that their claim of offering a next generation 3-BP is at least plausible.

MD Anderson has developed what they call a third generation glycolysis inhibitor, 3-BrOP (Glycolysin).

http://www.cancercuremedicine.com/news-md-anderson-3-brop-or

3-bromo-2-oxopropionate-1-propyl ester (3-BrOP)

Instructions are provided on the patent on how to make it.

``In specific aspects, a Glycolycin composition is synthesized by proper esterification of 3-halo-2-oxopropionate with an alcohol, or by stabilization of 3-halo-2-oxopropionate with sodium carbonate or sodium bicarbonate. The ester of 3-halo-2-oxopropionate is propyl 3-bromo-2-oxopropionate (which may be referred to herein as Glycolycin, also referred to as 3-bromo-2-oxopropionic acid propyl ester or propyl 3-bromopyruvate), ...

http://www.freepatentsonline.com/y2006/0058383.html

This is a ten year old patent.

The proprietary formulation named on the site from The Phillippines is X-Gly. In the application MD Anderson called their product Glycolycin, M-Glycolycin, E-Glycolycin, S-Glycolycin, ... Perhaps the next generation formulation that they claim is being used is simply the chemical from the patent. It might take very minimal infrastructure to synthesize it.

Another powerful reformulation

Chem Sci. 2015 Mar;6(3):1832-1845. The energy blocker inside the power house: Mitochondria targeted delivery of 3-bromopyruvate.

and also

Clin Cancer Res. 2014 Dec 15;20(24):6406-17. doi: 10.1158/1078-0432.CCR-14-1271. Epub 2014 Oct 17. Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer.

Such formulations would definitely up the ante. We should be looking out for these new formulations reaching clinic. It is possible that the clinic in The Philippines has accessed this new generation of product. Perhaps what happens is these new products would be trialed there and then when everything checks out they introduce them in Western clinics.

Such products would likely be at least 20 years from regulatory approval in the US. The ant-cacner effects of 3-BP were discovered in November 2001. Yet, a phase 1 trials has not even started! Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterDanielus
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RE: Anyone used 3bp (3-bromopyruvate)?
by Danielus on Mon May 18, 2015 03:22 PM Quote | ReplyDear Audiop, thank you very much for the feedback provided.

Reagrding Cytoluminator, I think that is clear: he is jumping from time to time here to advertise his cinic. In every of his intervention, he adds a link to his clinic. Yet his whole story is poor. One more point: those who realy make great discoveries (such as he claims) do not need to call the work of others "garbage". With that, I think we better focuss our attention on something that helps as evolve our knowledge.

For example, Jcancom added a very good link in the previous comment, a link to the patent on Glycolycin. Essentialy, that is 3BP+NaBic, claiming a better stability compared to e.g. the patent of Geschwind. In the same patent they discuss the liposomes version of 3BP.

That makes me wonder, what stops us making liposomal 3BP? That can be easly done at home in the same way as liposomal Vitamin C by sonication.

The goal of this approach would be to increase the bioavailability of oral 3BP to the level of  IV 3BP.

Anybody has an oppinion on this? Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterGenelle
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RE: Anyone used 3bp (3-bromopyruvate)?
by Genelle on Mon May 18, 2015 04:18 PM Quote | ReplyDr. Gonzalez dismantles the ketogenic diet for cancer -www.chrisbeatcancer.com/dr-gonzalez-dismantles-ketogenic-diet-for-can...* I don’t care how good the science sounds. Survivors trump science. And until we have a substantial list of long term survivors, I cannot in good conscience promote ketogenic diet as a viable option for healing cancer.

I am perfectly ok with being proven wrong, and if so, I will freely admit it, but it will be at least 10 years before we know if this really works for people, long-term.

Having said all that, if a protocol like the one I described above did not work, I would certainly be open to try to heal with a ketogenic diet over chemotherapy. It just wouldn’t be my first choice.

Here is a short video in which Dr. Gonzalez explains why he thinks a ketogenic diet doesn’t work for cancer. Just to recap, Dr. Gonzalez uses nutrition to heal cancer, putting his patients on a variety of diets based on their cancer and other factors. Simply put, if the ketogenic diet worked, this is a doctor who would be using it. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterGenelle
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RE: Anyone used 3bp (3-bromopyruvate)?
by Genelle on Mon May 18, 2015 04:18 PM Quote | ReplyDr. Gonzalez dismantles the ketogenic diet for cancer -www.chrisbeatcancer.com/dr-gonzalez-dismantles-ketogenic-diet-for-can...* I don’t care how good the science sounds. Survivors trump science. And until we have a substantial list of long term survivors, I cannot in good conscience promote ketogenic diet as a viable option for healing cancer.

I am perfectly ok with being proven wrong, and if so, I will freely admit it, but it will be at least 10 years before we know if this really works for people, long-term.

Having said all that, if a protocol like the one I described above did not work, I would certainly be open to try to heal with a ketogenic diet over chemotherapy. It just wouldn’t be my first choice.

Here is a short video in which Dr. Gonzalez explains why he thinks a ketogenic diet doesn’t work for cancer. Just to recap, Dr. Gonzalez uses nutrition to heal cancer, putting his patients on a variety of diets based on their cancer and other factors. Simply put, if the ketogenic diet worked, this is a doctor who would be using it. Quote | Reply

=Anyone used 3bp (3-bromopyruvate)?= View all Alternative Treatments Discussions Post A New Discussion947 Posts | Page(s): Prev 12...85 86 87 88 89 ...9495 Next Jcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Mon May 18, 2015 04:27 PM Quote | ReplyRumors are suggesting that German clinics are willing to infuse 3-BP for 100 euros.

This might not ultimately change total cost of care that much, though it is a consumer friendly pricing strategy that many on this thread might appreciate. Sort of like a pay by installment plan. Plinking down 30K without a chance to opt out along the way would be tough for most people. Taking a pay by the day approach would put  3-BP into the budget of, well, everybody. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Mon May 18, 2015 04:45 PM Quote | Reply3-BrOP actually has 3 more carbons on the end. This would probably be better than 3-BP (which is what is claimed in the patent).

(See May 18, 2015's (today's) posts).

http://www.longecity.org/forum/topic/73453-is-3-bromopyruvat Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterjames-peters
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RE: Anyone used 3bp (3-bromopyruvate)?
by james-peters on Mon May 18, 2015 04:51 PM Quote | Reply<p class="quoteDetails">On May 18, 2015 8:18 PM Genelle wrote:

Dr. Gonzalez dismantles the ketogenic diet for cancer -www.chrisbeatcancer.com"" target="_blank" rel="nofollow">http://www.chrisbeatcancer.com" target="_blank" rel="nofollow">www.chrisbeatcancer.com /dr-gonzalez-dismantles-ketogenic-diet-for-can...* I don’t care how good the science sounds. Survivors trump science. And until we have a substantial list of long term survivors, I cannot in good conscience promote ketogenic diet as a viable option for healing cancer.

I am perfectly ok with being proven wrong, and if so, I will freely admit it, but it will be at least 10 years before we know if this really works for people, long-term.

Having said all that, if a protocol like the one I described above did not work, I would certainly be open to try to heal with a ketogenic diet over chemotherapy. It just wouldn’t be my first choice.

Here is a short video in which Dr. Gonzalez explains why he thinks a ketogenic diet doesn’t work for cancer. Just to recap, Dr. Gonzalez uses nutrition to heal cancer, putting his patients on a variety of diets based on their cancer and other factors. Simply put, if the ketogenic diet worked, this is a doctor who would be using it. Dr. Gonzalez confuses the ketogenic diet with the Atkins diet Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterjames-peters
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RE: Anyone used 3bp (3-bromopyruvate)?
by james-peters on Mon May 18, 2015 04:54 PM Quote | Reply<p class="quoteDetails">On May 18, 2015 7:22 PM Danielus wrote:

Dear Audiop, thank you very much for the feedback provided.

Reagrding Cytoluminator, I think that is clear: he is jumping from time to time here to advertise his cinic. In every of his intervention, he adds a link to his clinic. Yet his whole story is poor. One more point: those who realy make great discoveries (such as he claims) do not need to call the work of others "garbage". With that, I think we better focuss our attention on something that helps as evolve our knowledge.

For example, Jcancom added a very good link in the previous comment, a link to the patent on Glycolycin. Essentialy, that is 3BP+NaBic, claiming a better stability compared to e.g. the patent of Geschwind. In the same patent they discuss the liposomes version of 3BP.

That makes me wonder, what stops us making liposomal 3BP? That can be easly done at home in the same way as liposomal Vitamin C by sonication.

The goal of this approach would be to increase the bioavailability of oral 3BP to the level of  IV 3BP.

Anybody has an oppinion on this? Dr Levy's take http://www.peakenergy.com/articles/nh20140411/Exposing-the-t and http://www.qualityliposomalc.com/ Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterDanielus
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RE: Anyone used 3bp (3-bromopyruvate)?
by Danielus on Mon May 18, 2015 05:09 PM Quote | Reply<p class="quoteDetails">On May 18, 2015 8:54 PM james-peters wrote: <p class="quoteDetails">On May 18, 2015 7:22 PM Danielus wrote:

Dear Audiop, thank you very much for the feedback provided.

Reagrding Cytoluminator, I think that is clear: he is jumping from time to time here to advertise his cinic. In every of his intervention, he adds a link to his clinic. Yet his whole story is poor. One more point: those who realy make great discoveries (such as he claims) do not need to call the work of others "garbage". With that, I think we better focuss our attention on something that helps as evolve our knowledge.

For example, Jcancom added a very good link in the previous comment, a link to the patent on Glycolycin. Essentialy, that is 3BP+NaBic, claiming a better stability compared to e.g. the patent of Geschwind. In the same patent they discuss the liposomes version of 3BP.

That makes me wonder, what stops us making liposomal 3BP? That can be easly done at home in the same way as liposomal Vitamin C by sonication.

The goal of this approach would be to increase the bioavailability of oral 3BP to the level of  IV 3BP.

Anybody has an oppinion on this? Dr Levy's take http://www.peakenergy.com/articles/nh20140411/Exposing-the-truth-about-liposomal-nutrients/"" target="_blank" rel="nofollow">http://www.peakenergy.com/articles/nh20140411/Exposing-the-t target="_blank" rel="nofollow">http://www.peakenergy.com/articles/nh20140411/Exposing-the-t and http://www.qualityliposomalc.com/"" target="_blank" rel="nofollow">http://www.qualityliposomalc.com/" target="_blank" rel="nofollow">http://www.qualityliposomalc.com/ Thanks for the links. What would be your msg based on the links?

The first link suggests that everything done at home will not end up as a liposomal version. Yet, when I was looking into this one year ago I remember that the same technique used for home preparation is used in the lab which is than checked with various analysis tools indicating indeed liposomals as outcome. Again, based on what I remember the liposomal done at home would typiclaly be at about 60-70% compared to the one produced in a specialized lab. But maybe you have more references on this subject? Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Mon May 18, 2015 06:01 PM Quote | ReplySomething that is bothering me about the clinic in The Philippines is the dosing. If I were wanting to aggressive claims about a 3-BP product, I would probably could do better than their claims. For example, their site makes a big point of how their new super formulation of 200 mg is vastly superior to that of the old formulation with 700 mg.

This does not appear that fantastic. The metastatic melanoma patient received a 130 mg dose of IV 2-BP. Considering his response to combo treatment with paracetamol, the new dosing guidelines might now be less than 30 mg.

Second or third generation 3-BP might be able to treat with a few mg or less. If minicells were used the dosing would be on the order of nanograms. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterDanielus
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RE: Anyone used 3bp (3-bromopyruvate)?
by Danielus on Mon May 18, 2015 06:17 PM Quote | Reply<p class="quoteDetails">On May 18, 2015 10:01 PM Jcancom wrote:

Something that is bothering me about the clinic in The Philippines is the dosing. If I were wanting to aggressive claims about a 3-BP product, I would probably could do better than their claims. For example, their site makes a big point of how their new super formulation of 200 mg is vastly superior to that of the old formulation with 700 mg.

This does not appear that fantastic. The metastatic melanoma patient received a 130 mg dose of IV 2-BP. Considering his response to combo treatment with paracetamol, the new dosing guidelines might now be less than 30 mg.

Second or third generation 3-BP might be able to treat with a few mg or less. If minicells were used the dosing would be on the order of nanograms. I think they reffer to Geschwind's patent suggesting 17mg/kg: US 20100203110 A1. But Geschwind is using NaOH as a buffer which seems to destabilize 3BP. This is why they may need 17mg/kg in contrast to the melanoma case where only 2mg/kg was used withouth buffer. Their new super formuation may be 3BP with saline alone :D, i.e. melanoma case. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Mon May 18, 2015 06:25 PM Quote | ReplyYeah, but when they combined 2.2 mg/kg IV 3-BP with paracetamol they cured the melanoma patient in two doses! (I do not understand why the poster was highlighting the possible toxicity of paracetamol: I would tend to want to minimize the dosing of the somewhat unknown quantity of 3-BP).

We need another patient to figure out what the new safe dosing regimen is with this combination (i.e. to avoid TLS). As a guess I suggest 0.5 mg/kg, though I would not even be comfortable with that dose. With 3-BP we would need to start at truly minimal dosing and dose up until there was an effect. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterDanielus
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RE: Anyone used 3bp (3-bromopyruvate)?
by Danielus on Mon May 18, 2015 06:36 PM Quote | ReplyBased on the info I have today, I would not be to concerned with TLS + I think 2mg/kg with some Paracetamol (1.5g/day) from time to time should be around the effective dose. Some Natrium Bic is needed to avoid the vein inflamation. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Mon May 18, 2015 06:41 PM Quote | ReplyWow!! It just registering liposomal 3-BP!

It might be simialar the encapsulation already reported, though this would be a do it yourself kitchen project. It might be able to get around the entire IV route problem. Quote | Reply

=Anyone used 3bp (3-bromopyruvate)?= View all Alternative Treatments Discussions Post A New Discussion947 Posts | Page(s): Prev 12...86 87 88 89 90 ...9495 Next Jcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Mon May 18, 2015 06:54 PM Quote | ReplyWould liposomal 3-BP even need to be sterile? Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Tue May 19, 2015 11:31 PM Quote | ReplyLiposomal 3-BP has me worried. It really seems best with 3-BP not to try to be too creative. Simply adding paracetamol massively increased the power of 3-BP. It would probably be well advised to stick to protocols that have been tried in humans.

I am not sure how liposomal 3-BP would actually work to treat cancer. Research has been accumulating that the current formulations of 3-BP is bound to proteins in the blood, has preferential access to cancer cells via MCT1, lastest research found acidic environment of tumors helps with uptake etc. . I am worried that liposomal 3-BP might  just gain entry to normal cells without the selective uptake offered currently by  3-BP. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Wed May 20, 2015 12:27 AM Quote | Reply"However, animal studies have shown that in its free, nonencapsulated state, the drug is very toxic [i.e. 3-BRPA], ..."

"The toxicity associated with the free-form version of the drug, he says, has prevented physicians from using the drug as a systemic treatment in people, one that can travel throughout the whole body."

Interesting to know that the reason why 3-BP hasn't become a widespread treatment is the toxicity.

http://www.sciencedaily.com/releases/2014/12/141217161629.ht Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterDanielus
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RE: Anyone used 3bp (3-bromopyruvate)?
by Danielus on Wed May 20, 2015 02:27 AM Quote | ReplyDear Jcancom, your last post is missleading. Maybe is not what you intended to state, but now it looks like you are worried regarding the toxicity.

I thought we clarified this point many months ago: Until now, Geschwind patented "free" 3BP stating that it is non toxic ... Now, once he developed the encapsulated form, he is saying 3-BP is toxyc withought his encapsulation. Lets not forget that Geschwind is the same guy who learned about 3BP from dr. Ko and than patented 3BP separately. Prof. Pedersen and Dr. Ko were very dissipointed regarding the actions of Geschwind.

So far, 3BP has been used on humans and the published results clearly state the fact that 3BP is low to notntoxic. Due to its very low to no toxicity 3BP is now rapidly addopted by many private clinics across the world.

You could even say 3BP is the perfect anti-cancer element: strong anti-cancer effect, relevant for most cancers, non-toxic, low cost and water soluble.

The only point you need to manage when administrating 3BP is its acidity which may lead to vein inflamation. But that can be managed. Vitamin C is also acidic and needs to be managed in a similar way ... Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJagdon
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jagdon on Wed May 20, 2015 03:52 AM Quote | Reply<p class="quoteDetails">On May 20, 2015 6:27 AM Danielus wrote:

Dear Jcancom, your last post is missleading. Maybe is not what you intended to state, but now it looks like you are worried regarding the toxicity.

I thought we clarified this point many months ago: Until now, Geschwind patented "free" 3BP stating that it is non toxic ... Now, once he developed the encapsulated form, he is saying 3-BP is toxyc withought his encapsulation. Lets not forget that Geschwind is the same guy who learned about 3BP from dr. Ko and than patented 3BP separately. Prof. Pedersen and Dr. Ko were very dissipointed regarding the actions of Geschwind.

So far, 3BP has been used on humans and the published results clearly state the fact that 3BP is low to notntoxic. Due to its very low to no toxicity 3BP is now rapidly addopted by many private clinics across the world.

You could even say 3BP is the perfect anti-cancer element: strong anti-cancer effect, relevant for most cancers, non-toxic, low cost and water soluble.

The only point you need to manage when administrating 3BP is its acidity which may lead to vein inflamation. But that can be managed. Vitamin C is also acidic and needs to be managed in a similar way ... Greetings!I am integrative cancer physician in India.I have been closely following the posts on 3BP on cancers with very useful information here.I am very mucj interested to use 3BP for cancer patients here that are mostly low class income group annd can't afford expensive,ineffective,mainstream treatments for advanced cancers.There are no 3BP centres/doctors here in India.I couldn't find a source of 3BP also here.My opinion is 3BP could be game changer in treatment for cancers especially for poor cancer patients.My interest is to provide 3BP treatments for my cancer patients at Rs.5000(USD 80 each sitting).Other treatments like VITC e.t.c,patients can manage at home or at private clinics.This was I would like to cater to cancer patients.I would request anybody who could provide me entire details preferably who have been trained and given 3BP i.v.Also the source of genuine 3BP.I need entire 3BP i.v.protocal from begining of preparation to i.v.administration,after follow ups e.t.c,Thanks for your consideration. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterGenelle
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RE: Anyone used 3bp (3-bromopyruvate)?
by Genelle on Wed May 20, 2015 05:09 AM Quote | ReplyWen you get this information and have success please let us know what you have done as there are poor cancer patients here too. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterDanielus
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RE: Anyone used 3bp (3-bromopyruvate)?
by Danielus on Wed May 20, 2015 03:15 PM Quote | ReplyThank you for sharing with us your thoughts. Wold 80USD/IV target the poor in India?

Yes, it would be great if you could share with us the results you will get. If you need that clear protocol for administration, folllow up etc. it may be a good idea to contact one of the clinics that are administrating 3BP? They may even like to invest in your business. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterDanielus
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RE: Anyone used 3bp (3-bromopyruvate)?
by Danielus on Wed May 20, 2015 05:21 PM Quote | ReplyJaqdon, why dont you use Methylglyoxal?

It shouldl be available in India and the results were great.

http://www.cancer-therapy.org/CT/v4/B/HTML/17.%20Talukdar%20 Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterkcervantes
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RE: Anyone used 3bp (3-bromopyruvate)?
by kcervantes on Wed May 20, 2015 07:06 PM Quote | ReplyDaniel -

The results of the Methylglyoxal Study are great! Is this drug available in the US? Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Wed May 20, 2015 07:54 PM Quote | ReplyYes, methylglyoxal appears quite impressive.

It is chemically simialr to 3-BP. Are there other 3-BP analogues that have shown anti-cancer effects? Would be very interesting to test MG vs 3-BP head to head. The clinical study of Mg posted above used an oral dosing route. What synergies might arise? Quote | Reply

=Anyone used 3bp (3-bromopyruvate)?= View all Alternative Treatments Discussions Post A New Discussion947 Posts | Page(s): Prev 12...87 88 89 90 91 ...9495 Next Jcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Wed May 20, 2015 08:32 PM Quote | ReplyHow did you find this study? It is not indexed in Pubmed! Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Wed May 20, 2015 08:45 PM Quote | ReplyA special form of honey from New Zealand and Australia called Manuka Honey has quite a bit of methylglyoxal (38.4-761 mg/kg). Yet, most of the honey labeled as Manuka is fake.

http://www.manukahealth.co.nz/manuka_honey.cfm?page_obj_id=9

The article dosed orally at 30 mg/kg. Eating 2 kg of honey a day would be a challenge. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Wed May 20, 2015 10:03 PM Quote | ReplyThis article carries the study forward into a next phase.

Drug Metabol Drug Interact. 2008;23(1-2):175-210.

A brief critical overview of the biological effects of methylglyoxal and further evaluation of a methylglyoxal-based anticancer formulation in treating cancer patients. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Wed May 20, 2015 10:37 PM Quote | Reply"... the drug is very toxic [i.e. 3-BRPA], ... has prevented physicians from using the drug as a systemic treatment"

I provided this quote because it is in such contrast to the comments on our forum. The quote was from December 2014 and it was from a very knowledgable 3-BP researcher.

Not long after this article, several clinics in the United States started offering 3-BP treatment (presumably IV). From the best that we can tell there are quite a few other clinics around the world also offering 3-BP treatment. This does call into the accuracy of and motivation behind the above statement. It also might explain why doctors have been reluctant to treat with 3-BP.

It also gives us insight into what the mainstream public might believe about 3-BP and why more have not tried it. This is all the more frustrating because 3-BP was given to the liver and melanoma patient precisely because it was acknowledged that approved medicines could not help them. The patients who have decided that 3-BP is "very toxic" have likely received treatments that were much less effective and much more toxic than 3-BP (from current evidence 3-BP has appeared to resulted in only minimal side-effects).

When 3-BP is widely understood not to be "very toxic", there could be a surge in interest in it.

Earlier in the thread I also noted that an extensive list of alternative treatments for cancer were considered to be quack medicine. 3-BP was not on the list. I found this reassuring.

Knowing what the critics are saying can be useful. It is especially interesting when we can find quotes which subsequently would seem to be unsubstantiated.

(Note the 2008 article on MG suggested that it IV administration might be possible. Would be very interesting to see how that would change effectiveness/ safety.)

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RE: Anyone used 3bp (3-bromopyruvate)?
by kcervantes on Thu May 21, 2015 12:02 PM Quote | ReplyAccording to the clinical study of MG the dosing was 8ml 4x day. Ive priced MG at $72 for 25ml = approx $504 week! Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Thu May 21, 2015 12:35 PM Quote | Reply$500? I doubt it! All of these simple molecules are super cheap. 1 million  grams of 3-BP costs $1000! (That should be enought to cure 1 million terminal cancer patients). Chinese suppliers  are selling MG for $1-10 /kg (98% purity).

The study said dosing was at 30 mg/kg. So about 2 g at 75 kg.

Sigma sells 25 ml of 1.17g/ml methylglyoxal for $77.70. Two 25 ml packs should last about a month.

http://www.sigmaaldrich.com/catalog/product/sigma/m0252?lang

I think I am starting to understand these claims of toxicity. Methylglyxal has been researched as part of the glycolysis pathway for over 100 years. MG's effectiveness as an effective cancer treatment was appreciated almost 50 years.

However, concerns about its toxicity prevented any further developement until 10 years ago. When MG was actually given to a fairly large group of humans over quite a long period of time (up to 5 years) in the clinical trial noted in the previous threads, there appeared to be no toxicity.

There are a whole shelfful of simple glycolysis inhibitors (e.g. 3-Bromopyruvate, methylglyoxal, 3-bromo-2-oxopropionate-1-propyl ester, probably others (Please post if you know of anymore!). Such simple molecules might have substantial problems moving forward more from the practical business side of enforcable patents instead of toxicity issues.

The oral dosing with MG might have advantages over IV 3-BP for treating colon cancer. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterkcervantes
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RE: Anyone used 3bp (3-bromopyruvate)?
by kcervantes on Thu May 21, 2015 12:44 PM Quote | ReplyJcancom -

Regarding your comment "The oral dosing with MG might have advantages over IV 3-BP for treating colon cancer." Why do you suggest this? My husband has colon cancer but its metastasized. Please elaborate. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Thu May 21, 2015 02:31 PM Quote | ReplyI just want to say that I defer to the big antlers on the thread for further clarification. I am sure we all know who that is.

I mentioned the colon angle because you mentioned it before.

The patents for 3-BP note that it could be administered in almsot any conceivable way--- transdermally, IV, inhalation .. orally etc. . 3-BP has only published papers with intraarterialy to the liver, and IV.

The interesting thing with MG was they used an oral fomulation. It seems intuitively plausible that dosing orally will result in better results (and safer ) for GI tumors. Effectively, oral dosing can specifically target the GI tract at higher doses than will occur systemically.

Consider the results that were obtained with mice when they nebulized 3-BP. It was noted that the treatment was more specifically targetted to the lungs, was more effective and safer.

The same might apply with oral dosing of MG.

When you look at the 2006 paper:

patients 5(E), 6, 9*, 17 Es (P), 23 C (E), 31(E), 33, 38(E), 39(E), 42 C (E), 44, 45 C.

{E is for excellent response,

P is for progressive disease, all the rest had an OK response, C is for colon caccer, and


 * is for the urinary bladder patient,

Es is esophagus which was the only GI patient with progessive disease even though symptomatic benefit was obtained with MG-- patient later  switched to chemotherapy.}

The paper listed 11 GI patients. I included 12 patients: including patient 9 with urinary bladder cacner which might not acutally be considered a GI patient.

Of the total set of patients in the clinical trial

18 (39%) had a complete response,

18(39%) had a partial response, and

8 (17%)  progessive disease (2 patients were lost to followup.)

Of the GI patients including (pateint 9)

6 (50%) had an excellent response,

5 (42%) had stable disease/normal life/partial response, while

1(8%) had progressive disease.

Of the colon cancer patients 23 E, 42 E (had met to lung), 45 stble (had met to liver). These patients before MG treatment were in serious condition.

Interestingly, the 2008 follow on study continued to report on the patients with a good response from the first study.

It appears that all 18 such patients had ongoing complete remissions. This includes colon cancer patients 23 and 42 (though, not 45). Some for up to 80 months! Sort of have to wonder how toxic MG could be if they received up to 2 grams of MG per day for almost 10 years!

Even still one of these patient died of a recurrence (patient 4 old number), one died of a heart attack (patient 13), and one opted out (patient 42 (one with colon cancer)).

These results are especially impressive considering the long term followup. Often cancer responses are short term.

Considering the mode of action of MG (and 3-BP) it seems reasonable to expect that short term responses would become long term responses as shown here.

Overall, it appears that oral dosing with MG can be effective for GI patients resulting in long term remissions. Caveats obviously apply.

These results never appear to have been verified anywhere. I am not sure whether safety studies have even been replicated. At the same time, you really have to wonder how dangerous honey could be! Mauka honey has a lot of MG up to 700 mg/kg. If this honey were toxic we would probably have hear of it by now. Never heard of Winnie the pooh being sick.

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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Thu May 21, 2015 02:41 PM Quote | ReplySorry everyone! T

The patients I listed: 5, 6, 9, 17 ... were all GI patients. (I did not clearly state that.) Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Thu May 21, 2015 03:50 PM Quote | Reply<p class="MsoNormal">The formulation of MG seems very simple. Note the literature suggests that vitamin C boosted MG's effectiveness. I am having a little bit of trouble with the numbers here. MG has a molar mass of 72g. 8 ml of 0.45 M Mg 4 times per day would give you 1.04 g of MG per day, shouldn't it? I am not sure how they got 1.8g (30 mg/kg/day x 60 kg). It looks like they gave everyone the same dose no matter what their mass. The molarity of the MG they used as treatment still seems pretty high (around 0.05 M). If MG were so dangerous how could they use such high molarity?

<p class="MsoNormal">With the 3-BP research they used injection with "Optimal results were obtained by delivering 25 ml 0.5 mM 3-BrPA,..."

<p class="MsoNormal">http://www.google.nl/patents/US8119116

<p class="MsoNormal">Sigma is selling 1.17 g / ml MG. This would be 16.3 molar. Need to dilute this down.

<p class="MsoNormal">"A stock solution of 0.45 M methylglyoxal is essentially the main component of the formulation to treat cancer patients. Methylglyoxal was obtained from either Sigma ..."

"Each patient received orally at a time 8 ml of 0.45 M methylglyoxal diluted in 60 ml of water, followed by a tablet of chewable vitamin C containing 400 mg of sodium ascorbate. The patients received this treatment 4 times/day at regular interval. Taking the drug on an empty stomach is not recommended. This is equivalent to the ingestion of 30mg methylglyoxal/kg of body weight/day, considering a person of 60 kg body weight. Each patient also received orally a mixture of the B vitamins twice a day: B15mg, B62.5 mg, B125mg and B57.5 mg. This mixture is usually a standard composition of vitamin B complex available."

i think another interesting point of note is how much of a dose boost you get going with oral dosing. As I mentioned before on this thread the melanoma patient received 130 mg IV injections of 3-BP with paracetamol, such treatment resulted in almost immediate complete tumor destruction. It would seem to me that dosing in future trials will have to be reduced quite a lot. Perhaps even 20 mg IV 3-BP combo would be too much.

In the present study with MG they gave 1-2GRAMSorally. I would not feel comfortable injecting 20 mg of MG! They pretty much drenched the entire GI tract with fairly high molarity MG. Very little of this was probably absorbed systemically. Oral dosing really seems to allow quite high amounts of MG to be directed to the GI tract. It would be interesting to know whether the GI patients had especially good responses to any GI mets, while perhaps not so much for mets outside of the GI tract.

Almost all GI patients felt better after MG treatment. This would be expected if their GI tumors were well controlled with treatment. MG treatment would probably make patients feel better especially if it could stop internal bleeding from GI tumors, such an outcome would seem quite possible. Quote | Reply

=Anyone used 3bp (3-bromopyruvate)?= View all Alternative Treatments Discussions Post A New Discussion947 Posts | Page(s): Prev 12...88 89 90 91 92 ...9495 Next Danielus
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RE: Anyone used 3bp (3-bromopyruvate)?
by Danielus on Thu May 21, 2015 04:39 PM Quote | ReplyThis is a nice one too on MG: http://www.cancerevolution.info/cancer-therapies/dca-therapy Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterDanielus
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RE: Anyone used 3bp (3-bromopyruvate)?
by Danielus on Thu May 21, 2015 04:39 PM Quote | ReplyThis is a nice one too on MG: http://www.cancerevolution.info/cancer-therapies/dca-therapy Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Thu May 21, 2015 05:38 PM Quote | ReplyWow! I just had to gasp when the article noted that this was understood by scientists in 1972 (This was a comment on research that had been conducted many years earlier). The War on Cancer began in 1971. It appears that victory could have been declared before the war had even been proclaimed.

Many references online accept without question the toxicity of methylglyoxal. For many decades, MG was a non-starter for even animal research. With 3-BP, the toxicity argument at face value is not easily dismissed. It does shut down cellular respiration in all cells at certain dose levels. It can be a strong alkylating agent. No human had ever been exposed to even a picogram of  3-BP before at the earliest 2001. 3-BP could be toxic.

However, with MG, people have been exposed to considerable doses, possibly forever. (The Manuka shrub tree originated in the Miocene-- that is 5.3 - 23 million years ago). Manuka honey has up to 720 mg/kg. It is possible that if someone were a honey addict they might have been dosed with up to 100 mg per day chronically. No particular toxicity has ever been reported for this honey. Instead Manukia honey is now used as an antibiotic treatment for wounds under the brand name Medihoney.

Given this, toxicity claims for MG seem very empty. It is possible that dosing up to 2 grams per day MG might have side-effects when given chronically. However, the patients who received it at that dose for 10 years ( as of 2008, perhaps some have now been treated for up to 17 years!) did not appear to show any toxicity. Many would likely not have lived as long as they did without the treatment.

{Someone should do a comprehensive search of all antibiotic treatments. It is amazing how many of these anttibioitcs are turning up as cancer treatments. Salinomycin, deoxycycline, 3-BP (fungicide), ... . It sure makes sense that if you want to specifically target mutant cancer cells then targetting  abnormal prokaryotic mitochondria is probably a very good place to start.}

[Someone, preferably not me, should really do a comprehensive search of all pyruvate like molecules in search of ones with anti-cancer properties. There are probably are quite a few. The give away with MG is that it has long been understood to be related to glycolysis. }

Article noted that MG could help when combined with DCA. No mention of 3-BP. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Thu May 21, 2015 09:31 PM Quote | ReplyThis has been out there for a long time.

The research actually dates back to 1963. MG treatment has been given to people decades ago as Koch Therapy. These patients also had impressive results.

http://www.com--www.com/killcancernow.com/methylglyoxal.html Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Thu May 21, 2015 11:21 PM Quote | ReplyHi all!

We have been using a fairly non-systematic method to find pyruvic acid analogues. I am not sure how exactly methygloxal was found or even 3-bromopyruvate, though probably more or less by the hit and miss method. We could always be more organized than that.

Why not search for all chemical structures similar to pyruvic acid (or pyruvate)? We want something that is similar to pyruvate, an analogue, though something that is different enough to mess up glycolysis.

The below website found all analogues to pyruvic acid. There were 779  structures found (argh!).

Quess what? 3-Bromopyruvate popped up early on (page 4 bottom row, second from the left) and Methylglyoxal (first structure on page 29).

This could be a fairly easy way to find other glycolysis inhibitors that we might have missed out on. It might take a little time to figure out how to use chemists' tools to organize and filter through all these hits! Sure would be nice if we could just filter through all these 700 structures that have references to cancer.

Several compounds on page 33 seemed to stand out, one was even used as a herbicide which seems interestng.

3-BrOP might have been among the 700 though I didn't spot it. Would be great if you could filter down the molecules with ones that had bromine in them.

We could make a group project to work through all these. This is relevant because other glycolysis inhibitors if they exist should be among these 700.

It would be much easier than randomly reading through all the old research for leads, as some of that research stretches back to over 50 years ago!

http://www.chemicalize.org/search/#m=pyruvic%20acid/t=t/h=58 Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Fri May 22, 2015 01:39 AM Quote | ReplyUsing page counts in chemicalize searches can really help to narrow down. For example, the pyruvic acid search MG had 204 pages, 3-BP had 38. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterDanielus
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RE: Anyone used 3bp (3-bromopyruvate)?
by Danielus on Fri May 22, 2015 07:10 PM Quote | ReplyFDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1.Musdal Y1, Hegazy UM, Aksoy Y, Mannervik B.Author informationAbstractOBJECTIVE: Glutathione transferase P1-1 (GST P1-1) is often overexpressed in tumor cells and is regarded as a contributor to their drug resistance. Inhibitors of GST P1-1 are expected to counteract drug resistance and may therefore serve as adjuvants in the chemotherapy ofcancer by increasing the efficacy of cytostatic drugs. Finding useful inhibitors among compounds used for other indications would be a shortcut to clinical applications and a search for GST P1-1 inhibitors among approved drugs and other compounds was therefore conducted.

RESULTS: We identified chlorophyllide, merbromine, hexachlorophene, and ethacrynic acid as the most effective GST P1-1 inhibitors with IC50 values in the low micromolar range. For comparison, these compounds were even more potent in the inhibition of human GST A3-3, an enzyme implicated in steroid hormone biosynthesis. In distinction from the other inhibitors, which showed conventional inhibition patterns, the competitive inhibitor ethacrynic acid elicited strong kinetic cooperativity in the glutathione saturation of GST P1-1. Apparently, ethacrynic acidserves as an allosteric inhibitor of the enzyme. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Fri May 22, 2015 07:31 PM Quote | ReplyEveryone, I took the chemicalize's site simiality results for pyruvic acid (779 results) and filtered down by linked pages ( 20 or more). There were 131 results (including pyruvic acid).

Many of the results of belong to closely defined families 9for example, for some reason there is quite a bit of interest in oxalate (81-87). They seemed to have added every metal they could think of to oxalate. I wonder why the result did not return every combo like 3-Bromopyruvate.?).

This list is fairly important. Decades ago Nobel prize winning scientists wanted to find analogues for pyruvate to deplete cancer of energy. It would have taken quite a bit of effort to assemble the list I have included below. We can take advantage of all the research that has taken place over the last several decades to see what molecules the scientific community found especially interesting.

I am quite impressed how high up the list 3-BP is. ({#17},though there are not that many linked pages.) Methylglyoxal (#100) is also on the list. Using a more systematic approach to finding glycolysis will make it easier not to miss out on attractive candidates like MG. Simply reading journal articles would not help that much.

At least 2 of the 131 on the list appear to be hits.There might be others. The list could be further invesigated and narrowed down: there appear to be quite a few lactic acids/lactates that really are not going to be that helpful.

Also  go tme thinking about how glucose similars might help out. (List has molecule nubmer, number of page links, similarity score, molecule name.)

1.  3276   1.00 pyruvate 2.  483      0.95 sodium pyruvate 3.     25     0.90 hydroxypyruvic acid 4.     75     0.86  mesoxalic acid 5.   335     0.79  2-ketobutyric acid 6.      72    0.79  2-oxobutanoate, 2-ketobutyrate 7.      52    0.73  methylpyruvate 8.   2258  0.68  propionic acid 9.  2816   0.68  propionate 10.  207    0.68  carboxyethyl 11.   93    0.68  2-arylpropionic acid 12.  675    0.68  polyacrylic acid 13.    38    0.68  long-chain fatty acid 14.    34    0.68  arylpropionic acid 15.   959   0.68   malonic acid 16.    904    0.68   malonate 17.      38    0.68   3-bromopyruvate 18.      38    0.68   3-mercaptopyruvate 19.      21    0.68   3-mercaptopyruvic acid 20.      63    0.67   3-hydroxypropionate 21.     138    0.67   3-hydroxypropionic acid 22.       24     0.67   malonic semialdehyde, opropionic acid 23.      182     0.67   malonyl 24.       291     0.66   3-methyl-2-oxobutanoate 25.       169     0.66   alpha-ketoisovalerate 26.      26     0.66    2-oxopentanoic acid 27.      23     0.65    sodium malonate 28.    208     0.65   sodium propionate 29.      55      0.65  potassium propionate 30.     143    0.65  sodium polyacrylate 31.     103    0.65   calcium propionate 32.      43    0.65   calcium propanoate 33.     232     0.65   glyoxylate 34.     237     0.63    glyoxylic acid 35.       199     0.63   acetone water 36.      71      0.61    oxalyl 37.     432       0.60   dihydroxyacetone 38.      92        0.60   methylmalonic 39.      22        0.60   2,2-dimethyl-malonic acid 40.      70         0.60  methylmalonate 41.       68        0.59  ethyl 2-oxopropanoate 42.       43        0.59  2,2-dimethylpropanoate 43.    437       0.59   isobutyric acid 44.     923       0.59   pivalic acid 45.     395       0.59    isobutyrate 46.       22        0.59    2-oxobutoxy 47.     284       0.59   polymethacrylic acid 48.       72       0.58     lactic acid 49.    2892      0.58 lactate 50.     1125     0.58  lactic acid 51.      184      0.58   2-carboxy-1-hydroxypropan-2-yl 52.      211     0.58  2-methyl-3-oxopropanoic acid 53.      2855   0.58  propel, D-lactate 54.        179   0.58   3-hydroxyisobutyrate 55.        171 0.58     L-lactic acid 56.        162  0.58   L-lactate 57.        45   0.58    2-2-bis(hydroxymethyl_ propionic acid 58.        25  0.58    hydroxypivalic acid 59.       231 0.58   oxalacetic acid 60.        648  0.58      oxaloacetate 61.             1094  0.57    oxalic acid 62.            1282 0.57     oxalate 63.     275 0.57       hydrogen oxalate 64.     45 0.57         oxalic acid dihydrate 65.    1296 0.57    butryic acid 66.    2064 0.57    ethylacetate 67.    151 0.57      carboxymethylethyl 68.    212 0.56      sodium lacate 69.    152 0.56      calcium lactate 70.    21 0.56        potassium lactate 71.    54 0.56        magnesium lactate 72.    24 0.56       silver lactate 73.    74 0.56       zinc lactate 74.    160 0.56   ammonium lactate 75.    20 0.56     potassium lactate 76.    26 0.56     alpha-ketoadipic acid 77.    86 0.56     tartronic acid 78.    141 0.55   calcium oxalate 79.    45 0.55     calcium oxalate monohydrate 80.    26 0.55     calcium oxalate dihydrate 81.    74 0.55     ammonium oxalate 82.    61 0.55    sodium oxalate 83.    24 0.55    silver oxalate 84.    50 0.55     potassium oxalate 85.    31 0.55     disodium oxalate 86.    138 0.55    cerium oxalate 87.    20 0.55     barium oxalate 88.    145 0.54     2-oxo-4-methylpentanoic acid 89.    28 0.54       4-methyl-2-oxopentanoate 90.    238 0.54    acetoin 91.    211 0.54   propionic acid methyl ester 92.    70 0.54      methoxycarbonylethyl 93.    104 0.54   sodium butyrate 94.    85 0.54     poly(methyl acrylate) 95.    105 0.54    glyceric acid 96.    60 0.54    glycerate 97.      229 0.54  acetoacetic acid 98.      274 0.54  acetoacetate 99.        45 0.53  pentane-2,4-dionate 100.    204 0.53  methylglyoxal 101.    29 0.52  dihydroxy acetone 102.    54 0.52  3-butenoic acid 103.     96  0.52   vinylacetate 104.    508 0.52   BPL, propiolactone 105.      84 0.52   acetonate 106.      71 0.52   beta-lacetone 107.   130  0.52   dimethyl malonate 108.      31 0.52   aluminium acetoacetate 109.  1834 0.51   alpha-ketoglutarate 110.    594 0.51   alpha ketoglutarate 111.  2904 0.50   4-hydroxybutyrate, GHB 112.    30 0.50   3-chloropropionic acid 113.   955 0.50     methacrylic acid 114. 1159 0.50     gamma-hydroxybutyric acid 115.   166 0.50     3-mercaptopropionic acid 116.    618 0.50    beta-alanine 117.    40 0.50    succinate semialdehyde 118.    81 0.50    cyanoacetic acid 119.     137 0.50    succinic semialdehyde 120.   1096 0.50    methacrylate 121.    37 0.50     cyanoacetate 122.    26 0.50      3-mercaptopropionate 123.    28 0.50      methyl iodide-acetic acid 124.    27 0.50     bromopropionic acid 125.    60 0.50    reuterin, oxopropoxy 126.    46 0.50    aminopropionate 127.    23 0.50    methyl 3-methoxypropionate 128.        26 0.50    trifluoromethylacetic acid salt 129.        92 0.50     bromopropylate 130.      130 0.50    alkyl methacrylate 131.     32 0.50     hydroxyalkyl (meth)acrylate

Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Fri May 22, 2015 10:00 PM Quote | ReplyI am impressed at the effectiveness of the similarity search. This is a very powerful method to narrow down the search space. 3-BP and MG quickly emerged from the search. We have been searching for these molecules for years: this search found them immediately. The list is actually even much smaller than it seems at first glance. Many of the compounds belong to only a few larger families.

It was disappointing that DCA, and 3-BrOP (possibly phenyl butyrate) did not appear on the screen. DCA is just too different and 3-BrOP is too big (though it could be considered an extension of 3-BP).

Wonder if Dayspring would offer methylglyoxal treatment. Considering that it is in honey, seems like a possible for an alternative clinic.

Any comments on my suggestions about oral MG with respect to GI tract tumors? Trying different dosing routes with treatments that already have human clinical experience seems very reasonable. Being able to target 1.8 grams of 0.05 M Methylgloxal at the GI tract is a very inviting opportunity. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterDanielus
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RE: Anyone used 3bp (3-bromopyruvate)?
by Danielus on Sat May 23, 2015 02:56 AM Quote | ReplyHi Jcancom. Interesting research and list. Now you would have to take every component on the list and check if there is cancer research behind. On that list you can find a few more anti-cancer elements.

I dont understand why discussing MG for GI tumors specificallly? Is like discussing 3BP for GI only.

What is interesting to me is that the reports from India included so many people with very good results and university profesors performing these studies, and now is sillence. In the end, the same is with 3BP. Interesting world ...

=Anyone used 3bp (3-bromopyruvate)?= View all Alternative Treatments Discussions Post A New Discussion947 Posts | Page(s): Prev 12...89 90 91 92 93 ...9495 Next Jcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sat May 23, 2015 12:43 PM Quote | ReplyYeah, I was somewhat afraid that I would be nominated to work through the list (I posted the list because I thought maybe we could make this a group project. Everyone might take a couple of the molecule families and could report back.).

As I said the list is actually much shorter than it appears. There are about ten different lactates, oxalates, propionates, butyrates, acetates ... On careful inspection the list of unique chemical families is short. This makes it all the more impressive that 3-BP and MG popped up on it. Might have to look through all 779, though.

With all the interest in 3-BP, it does not make sense to me why they have not tried all the combinations with it. 3-fluoro-pyruvate, 3-chloro-pyruvate, 3-iodopyruvate, 3-astatinopyruvate. It appears there has not been any interest in these compounds.

Even with DCA you wonder if (mono-chloro-) DCA would make more sense.

Understanding the chemistry would obviously be helpful. What exactly is 3-BP interacting with and how in the body? Some of the structures found were not that similar to pyruvic acid. In fact some of them were quite scary (There were several tri-fluoros. They sound very dangerous.) The ones that seemed to help with cancer were quite similar to pyruvic acid (3-Bp and MG). Both mostly preserved the methyl end with 2 connected double bonded oxygens. The list could be further reduced by discarding those compounds that had no chemicomedical plausibility.

I am also interested now in modifications in glucose. This might also have implications for cancer.

My thinking on oral MG was just that we have quite a bit of human experience with it in that form. Both in the trial and with the honey. I thought that people who wanted to stick with glycolysis inhibitors that had actual human evidence for a particular route of administration, then they could go with MG orally. We have BP for TACE to the liver and IV in published human reports. We have MG for oral in published form. It would great now if we could have some inhalation and transdermal reports.

MG orally could really help out those with GI bleeds, I am just guessing on that, though it makes sense. Anyone have thoughts? All the GI patients in the trial at least felt symptomatically better with MG. This does not seem surprising because if MG does help with bleeds people would feel better quite quickly. Bleeds make feel patients run-down and paying for transfusions can become expensive.

There were some comments on the internet that the MG story is an example of a crime to deprive patients of a helpful medicine. It is pretty obvious looking at all of these pyruvic acid analogues that none could easily be brought forward as a commercial medicine. It would take almost no chemical knowledge to make your own.

The scientific community has been able to obscure this up to now because it was difficult for others to contest the claim that these substances would be toxic. It must have been believed that claiming methylglyoxal was toxic was not falsifiable. Apparently, it is. The discovery that a form of honey contains substantial amounts of MG seriously calls in to question the claim of toxicity.

If only pyruvic acid analogues were more complex, less accessible, and more patentable we would have cured cancer  a century ago. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sat May 23, 2015 02:09 PM Quote | ReplyI want those on the thread to know that the wiki is up and running.

http://3bromopyruvate.wikia.com/wiki/3-bromopyruvate_Wikia

Perhaps we could migrate some of our energies to the wiki, as it seems to have features that make communicating more effective. For example, if you follow the links through organization--> thread--> to our thread, you can search our entire thread for a keyword. I found this very helpful recently when I wanted to find references to phenyl butyrate. I would have had to read our entire thread to find these references. With our whole thread on one page on the wiki, there was no problem using the find function in my browser to locate the phenyl butyrate references immediately.

Also, the threads on the wiki ( click on the forum link to the left near the top of the wiki page) are all collapsed. This is very helpful. I am sure if I am feeling the love out there on this thread. Maybe I am just a big mouth who everyone wants to be quiet. On the wiki, I could start a thread on say minicells and if no one were that interested then I could get the message. Collapsed threads also make things a lot more easy to navigate and organize.

The wiki also has a place to share images. This would be very helpful when trying to explain glycolysis and how different inhibitors work.

There are quite a few possibilities with the wiki. We might just consider migrating our discussion over there.

Please post a comment in the forum of the wiki! Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterrwilliams214
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RE: Anyone used 3bp (3-bromopyruvate)?
by rwilliams214 on Sat May 23, 2015 05:08 PM Quote | Reply<p class="quoteDetails">On Jun 22, 2012 8:25 PMvivodoodwrote: <p class="quoteDetails">On Apr 19, 2012 8:16 PMaleydermwrote:

I would like to know if anyone used 3-bp? Any fedback.

Thanks

Anna I had multiple intravenous infusions of 3-bp over one month in 2011 with hopes to treat cancer. I am familiar with it because of reading the book by a PhD researcher by the name of Thomas Seyfried. The man who developed it was working with Dr. Seyfried in his lab. It is a awsome drug. It does not harm normal cells and targets the mitochondria which Seyfried clames is the solution to successful treatment. He has a book titled " Cancer as a Metabolic  Disease". Google U-tube with Dr. Mericola interviewing Dr. Thomas Seyfried. Cancer thrives on glucose and glutamine. Using 3bp and also a ketogenic diet both depleat energy from the cancer. The man mentioned a few before your message that used 3BP died because his liver could not tolerate so many cancer cells dying so rapidly.

The third one of the URL listings below tells the story.

I am not a physician, I am a dentist very interested in fewer people dying from cancer. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sat May 23, 2015 06:46 PM Quote | ReplyWelcome aboard!

This thread and cancer metabolism in general are really entering the limelight.The thread has been receiving posts from visitors from all over the world lately. It feels like if we could just light the match at the right place we could have ignition! We all know that it would not take many more positive reports to push 3-BP / MG etc. centre stage in cancer treatment. We need more patient reports!

I have contacted Cancer Compass about providing some Internet analytics to this thread. No answer. It would be very informative to know who (and where) the people reading this thread are.

Consider: A major cancer metabolism conference is going to happen in Boston in a few days. Most of the heavy weight pharmas will be there. It would not be totally unexpected if Prescience were to step up and say the first trial with 3-BP will now start! Hopefully, our operatives who will attend the conference will post info on the thread.

http://cancermetabolism-summit.com/wp-content/uploads/sites/

It really does not make sense to me that many of the top echelon of scientists and cancer researchers have advocated for the metabolic treatment approach for cancer for almost a century, though so few community level GPs seem to be with the program.

For example,

Otto Warburg winner of the 1931 Noebl prize in Medicine (for investigating metabolism of tumors and cellular respiration). He was nominated for a second Nobel in 1944. His book The Metabolism of Tumours (1931) might be the inspiration for books published on the same theme 80 years later.

Three others in his lab went on to win Nobels including Krebs (That would be Sir Hans Krebs of the Krebs cycle fame, i.e. the major stage of cellular respiration).

I could not find any mention of any of the Warburg lab ever finding a glycolysis inhibitor. However, another Nobel Prize Winner in Medicine (1937) Albert Szent-Györgyi  who also researched cellular respiration worked on methylgloxal as a cancer treatment. He published ground breaking research on methylglyoxal and cancer in Science (1963).

{The list that posted earlier of pyruvic acid analogues seemed to have quite a few compounds that might be called ketos. GHB really stood out for me.} Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sat May 23, 2015 07:54 PM Quote | ReplyThe original research by Szent-Gyorgi in 1963 made some very interesting initial impressions about retine (later called methylglyoxal).

http://www.ncbi.nlm.nih.gov/pubmed/13979937

"... Some extracts produced a strong inhibition of growth [of cancer] while others produced a promotion. ... a promoter, "promine" and a growth-retarding one "retine" ... growth promotion and inhibition depend indeed on the balance of two active substance. ... promine makes cancer cells gorw faster,  while retine tends to stop their growth and can make cancer already developed regress. ...

To achieve regression the ratio of the concentation of retine to promine has to be altered significantly. Cancer seems to regress when the ratio is doubled-- that is, when amounts of retine are injected daily which correspond roughly to the quantity of retine present in the animal's body. ...

retine produces no leucopenia... in one experiemnt the aortas of old animals contained less retine than those of young ones, which suggested aposible connection between a diminished concentration of retine and the increased incidence of cancer with advancing age...

we found indication of retine in the urine of children .... Muscle, tendon and big blood vesels are very rarely seats of cancer. This in our experience is not necessarily due to higher retine concentration .... However, muscle tendon and aorta have greater concentration of retine than proimne so that their extracts are inhibitory even before promine is removed,...

We found no harmful side effects either with retine or with promine. ... Retine and promine, being natural substances produced by nature, might perhaps specifically influence cell division" one might have here substances which will stop cancer growth and even produce regression without toxicity. Possibly even the growth promoting substance may acquire a medical application, in analogy to weed killer which kill by promoting growth. One could, perhaps, introduce in the body some anti-metabolite and then make the cancer grow fast and kill itself. The growth pormoter seems not to induce malignancy by itself. It might also find application in accelerating the healing of wounds."

For an article written in 1963 there is a lot that seems current... 50 years later.

I will be interested to read how the literature on retine (methylgloxal) continues from this article. aQuote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sat May 23, 2015 08:08 PM Quote | ReplyWow! This is very interesting.

In an article Cancerostatic Action of Methylglyoxal by the same author in the June 7, 1968 issue of Science, it is mentioned that  regarding "our work on methylglyoxal, whose derivative, Kethoxal (Upjohn), is used as a cancerostatic agent."

This is very interesting.

Is Kethoxal still marketed as a cancer treatment? Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sat May 23, 2015 10:03 PM Quote | ReplyFirst hit! Malonic acid (#15).

Beetroots cure cancer? This has been used for thousands of years. will have to investigate further.

http://undergroundhealthreporter.com/vegetables-for-cancer-b Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sat May 23, 2015 11:15 PM Quote | ReplyQuite a few of these already seem interesting.

-mesoxalic acid (#4) is a natural compound found in beet molasses (might be related to malonic acid)(see previous post for #15)

-methylpyruvate(#7) http://www.ncbi.nlm.nih.gov/pubmed/?term=3-Methyl+pyruvate+enhances+radiosensitivity+through+increasing+mitochondria-derived+reactive+oxygen+species+in+tumor+cell+lines

-propionic acid (#8) used to prevent mold in bread (see #31)

-propionate (#9) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494429/

-malonate (#16) is malonic acid with 2 hydrogen ions removed. Interestingly, it is a competitive inhibitor of a respiratory enzyme.

https://clinicaltrials.gov/ct2/show/NCT00409032 http://www.drclark.net/the-essentials/advanced/pollutants/ma

-malonyl (#23) [not sure if malonyl CoA is same thing]http://www.google.com/patents/EP1728510A2?cl=en

-sodium propionate (#30) used to prevent mold  in bread (see #31)

-calcium propionate (#31) Is used as a mold and anti-bacterial agent for bread. {This should mean that it is disrupting cellular respiration. Might have relevance to cancer.} Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 24, 2015 12:38 AM Quote | Replyammonium lactate (#74)  [in the lactate cluster from #68-#75, also #53, #55, #56.]

http://www.ncbi.nlm.nih.gov/pubmed/2915076 Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 24, 2015 01:17 AM Quote | ReplyImpressive, though perhaps not that surprising that so many of these compounds are coming back as hits. These compounds are all highly related and many would probably interfere with glycolysis.

butryic acid (#65)

http://www.ncbi.nlm.nih.gov/pubmed/19707587

tartronic acid (#77)

http://www.ncbi.nlm.nih.gov/pubmed/20699632

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=Anyone used 3bp (3-bromopyruvate)?= View all Alternative Treatments Discussions Post A New Discussion947 Posts | Page(s): Prev 12...90 91 92 93 94 95 Next Jcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 24, 2015 01:34 AM Quote | Reply- oxalic acid (#61) and

ammonium oxalate (#81)  (used as selective calcium chelators)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541088/ Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 24, 2015 01:59 AM Quote | ReplyThis seems quite important.

Apparently it is only recently that the mitochondrial pyruvate carrier was found. It will be interesting to see how this discovery can be translated into improved clinical care.

http://www.cancerandmetabolism.com/content/1/1/6 Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 24, 2015 02:02 AM Quote | Reply-pyruvate (#1)

http://www.cancerandmetabolism.com/content/3/1/2 Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 24, 2015 02:18 AM Quote | ReplyGreat if we could break into the pathways of all these compounds for example.


 * 1) 9--> #40 --> 20 [in certain patients]

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC389649/

As #109,#110 and #60 are just from the Krebs cycle. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 24, 2015 02:21 PM Quote | ReplyI have an idea.

DCA is one of the chemicals that helped relaunch the interest in glycolysis inhibitors. It has OK effectiveness in cancer, though perhaps due to its two chlorines side effects can emerge with its use ( e.g. neuropathy)

Going down the halogen column, we next wind up at bromine which is somewhat less electronegative than chlorine. 3-bromopyruvate has shown some impressive effectiveness in cancer patients with increased safety (over DCA).

Why don't we fund science studies of 3-iodopyruvate and possibly 3-astatopyruvate? I have come across something called scienceexchange.com. One of their founding partners is Johns Hopkins! Perhaps we could ask around at some other forums and start up an Indiegogo crowdfunding campaign. Making and testing these compounds in cancer cell lines probably would not cost very much money.

I searched for 3-iodopyruvate and 3-astatopyruvate for online sellers: there aren't any. If pharma could see a way to a viable patentable anti-glycolytic they might be interested. It seems reasonable to expect that both 3-iodopyruvate and 3-astatopyruvate should have anti-cancer effect and likely have improved safety over 3-BP.

We could do a free consult with the lab, beforehand to make sure this all made sense (and that patent issues wouldn't arise [Hopkins or someone else has probably already blank patented everything near 3-BP).

Why not be part of cancer research? 3-IP and 3-AP might be even better than 3-BP. Comments? Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterDanielus
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RE: Anyone used 3bp (3-bromopyruvate)?
by Danielus on Sun May 24, 2015 02:40 PM Quote | ReplyHi Jcancom, I think this is a good idea and is great if you could start such a cowdfunding. While scientificaly interesting, these components have not yet been investigated as anti-cancer elements. In order to get faster to a result that can be applied and save lifes, maybe you want to focuss on those that are already proven to be effective such as 3BP or MG and build on that? Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterkcervantes
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RE: Anyone used 3bp (3-bromopyruvate)?
by kcervantes on Sun May 24, 2015 03:12 PM Quote | ReplyI completely agree with Daniel. 3BP and MG have both shown to have impressive results with little to no side effects as long as they're administered properly. I believe all cancer patients can benefit from both of these drugs but the problem lies in purchasing from a reliable source and administration. If it was made plain and simple more people would be apt to try them. I will be starting my husband on a 3-BP regimine shortly and I will be more than happy to post our results in order to possibly help others. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 24, 2015 03:25 PM Quote | ReplyThank you very much! I was worried everyone would think it was a terrible idea. I was all ready to cry in my milk.

I was particularly interested in these compounds because they appear to have been largely overlooked. This is especially important because so many on the list of pyruvic acid analogues that I posted have anti-cancer effect. It is not difficult to predict that 3-IP and 3-AP will also have anti-cancer effect and improved safety. The only question would be whether they would be strong enough.

Apparently, no one has even bothered with 3-fluoropyruvate, as it would be likely to be very dangerous. As you move down the periodic table the halopyruvates should become tamer, yet hopefully not so tame as to be ineffective.

It is true that I do not want to distract attenton from the main focus of 3-BP and MG, though any explanation on indiegogo of why it would make sense to study 3-IP and 3-AP would surely involve a detailed description of the research and results with 3-BP. Many people would have never heard of any of this. They might conclude that 3-BP is good enough and not want to fund the campaign. At least the 3-BP message would get out there!

It would also be helpful that everyone could feel a part of such a science project. If people realized that plausibly (because of a lack of published research on 3-IP and 3-AP) this could be a cure for cancer they might just step up and toss in 20 for the cause.

Anyone have any rough idea of how much money would be required for such a project?

1. Make 10 grams of 3-iodopyruvate and 3-astatopyruvate

2.  Run some cancer cell studies with 3-IP, and 3-AP against 3-BP and DCA Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 24, 2015 03:45 PM Quote | ReplyThere will be many on this thread that will be very interested to see how administering 3-BP will work out.

Please keep us posted! Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterDanielus
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RE: Anyone used 3bp (3-bromopyruvate)?
by Danielus on Sun May 24, 2015 04:40 PM Quote | ReplyLets forget a bit about 3-IP and 3-AP which woul be fundamental research and think about 3BP and MG. If you wouldl write a project on that what wouldl you study? What would you like to know more about 3BP and MG?

I would have the financial capabilities, I would support a clinic to offer free 3BP treatments to cancer patients. With that, I would help some people to get access to the treatment while searching for the working points (i.e. administration type, dose, additional drugs/supplements, etc.). This wouldl be a good pupose for crowdfunding and I think you did mentioned this some weeks ago.

Another good pupose wouldl be to build up a structure taht can help cancer patients get access to 3BP and MG, similar to what Grouppe Kurosawa did helping cancer patients to get Methyl Jasmonate.

What do you think? Quote | Reply

=Anyone used 3bp (3-bromopyruvate)?= View all Alternative Treatments Discussions Post A New Discussion947 Posts | Page(s): Prev 12...91 92 93 94 95  Next kcervantes
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RE: Anyone used 3bp (3-bromopyruvate)?
by kcervantes on Sun May 24, 2015 04:55 PM Quote | ReplyDaniel -

I think this would be an amazing opportunity for so many cancer patients! Especially the ones who conventional treatment has failed and have no where else to turn. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 24, 2015 05:41 PM Quote | ReplyThat was what I thought as well, though no one on this thread stepped up for the offer of free 3-BP treatment money. I thought Dayspring would be the obvious clinic to work through. We could raise money through Indiegogo Life.

The only catch would be the person receiving the money would agree to release annoymized medical records regarding the treatment. In this way, all the people who supported the campaign would know that their donations would result in more clinical experience with 3-BP being acquired.

Just about everyone at some level lives in dread of cancer. Contributing to a 3-BP campaign would not only help the person receiving the treatment, but also everyone else who might be interested in 3-BP if it were needed for them, their family or others, but need more clinical proof. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterkcervantes
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RE: Anyone used 3bp (3-bromopyruvate)?
by kcervantes on Sun May 24, 2015 05:44 PM Quote | ReplyI think we're on to something amazing! Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterDanielus
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RE: Anyone used 3bp (3-bromopyruvate)?
by Danielus on Sun May 24, 2015 05:57 PM Quote | ReplyYes Jcancom, your idea was great and there was no reaction. But we better react latter than never :)

So, lets see if there is any reaction from Dayspring. If not, I can arrange for a clinic in Germany. Or better, lets have a clinic in US and one in Europe depending on the location of the patient accessing the funds.

Do we need a foundation to collect the funds or there are other ways as well? Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 24, 2015 06:27 PM Quote | ReplyThat's great! I did not understand why there was no response.

I thought what we could do would be to submit Dayspring's or another cancer center bank account as the nominated payee for the campaign. We would then be at arms length from the money.

These campaigns sometimes allow a minimum fundraising goal. This would be helpful as if someone say needed a minimum co-pay of let's say 10K they wouldn't feel obligated to pay more than they felt comfortable with. Perhaps we could arrange with the nominated clinic to provide straight 3-BP IV (possibly with paracetamol and MG). Possibly we could ask for a discount from the posted rate.

One thing I was worried about was figuring out how to award a winner. For example, we could have run it as a lottery, though this might add a ghoulish sense to the whole campaign. What might happen would be whoever won the lottery lived: while everyone else didn't.

It would probably be best to source someone from our thread.

One thing to be aware of with campaigns is that many of the campaigns raise no money. This mode of crowdfunding has become so popular that it is becoming much more competitive. We should be prepared for donor fatigue and little outside interest.

The one thing that could really help us though, is the support base that has been developed on this site and several other forums. This thread is drawing an international audience. It is probably the most active 3-BP site on the internet. That is why so many heavy weights keep popping up here (and why I keep humbly deferring ).

Our installed support base are quite interested in having more reported patients especially from a clinic offering a high standard of care. As I said we truly are all in this together. Many people here and elsewhere could be put in the true believer camp for 3-BP. Appealing to people's self-interest often pushes what might be an unsuccessful idea to a highly successful idea.

The published studies have been highly selected and probably have been chosen for specific clinical features that were expected to yield a favorable outcome. We can not be totally sure what those factors might be. So, we should all have realistic expectations going in.

Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterkcervantes
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RE: Anyone used 3bp (3-bromopyruvate)?
by kcervantes on Sun May 24, 2015 06:40 PM Quote | ReplyDo you not think that by simply making the 3-BP available to cancer patients with the knowledge of how to administer it PLUS someone to answer any/all questions within a timely manner isnt the best way to reach more cancer patients? Limiting the clinic to one place in Germany and one place in the US is limiting the amount of people you can help. Even tho its an amazing concept.

The biggest drawback for cancer patients is trying to find a reputable distributor that will sell it to you. Making it readily available to them at a decent price would be HUGE! And outlining the way to administer it whether it be orally, IV or topically is essential to the patients success. I say figuring out a way to do this would go above and beyond what you can do at 2 locations. Just a thought :) Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Sun May 24, 2015 07:08 PM Quote | ReplyAll of those concerns are all true.

It is probably best to think about this as trying to solve a problem from as many possible angles at the same time: any one particular may not be necessarily a better result for any one particular person. For many, spending 20-30K for one treatment round at a clinic simply might not make sense.

The thing that I was focussed on was that we only have two published reports with 3-BP. Each of them used a different approach. Even replicating the melanoma patient's response would be a great service to other cancer patients.The liver patient's report was published 3 years ago! Why are half a million Americans still dying of cancer? I doubt if there has been any significant change in life expectancy of end stage liver cancer patients in the last 3 years, even though it certainly helped that one patient.

There should be no reason why a cancer clinic could't take someone with an LDH of 4000 and bring it down to below 10 (as was done with the melanoma  patient). If we could report such a result to our campaign backers, many would feel that it was a miracle.

It would be like magic! (though informed thread readers would find this an entirely plausible outcome). Such a result would be newsworthy. I think I will defer to the more photogenic posters to do any media interviews.

Sure, I thought maybe we could fund the Indian poster, though even one patient treated within the context of high standard Western medicine would have substantial credibility. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJagdon
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jagdon on Mon May 25, 2015 09:53 AM Quote | ReplyThanks..I am an integrative physician in India treating cancer patients with holistic approach most of them are from lower and middle class.I was fascinated by the inexpensive 3 BP treatements to treat cancers.I wrote several mails to the alternative cancer treatment centers that treat cancers with 3 BP to know more about  intrinsic methods of employing i.v.3 BP but I have got no response so far.

Now I am intersted to try Methylglyoxal(MG) in cancer patients.As this is oral and MG more easily available for oral administration I would be interested to try MG on cancer patients free of cost provided if someone funds in this project.The funding should also cover tests like blood tests,tumour markers,scans,PET e.t.c.,

My main aim is to pass on this safe and effective protocol to all cancer patients that are in dire need and can't afford expensive and  mostly ineffective mainstream treatments for advanced cancers. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterGenelle
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RE: Anyone used 3bp (3-bromopyruvate)?
by Genelle on Mon May 25, 2015 10:35 AM Quote | ReplyDid you try the Atlanta clinic?

Call (770) 232-7883 to set an appointment. or email us atinfo@advancedrejuvenationinstitute.com.

Our Address: 4426 Tilly Mill Road Atlanta, Georgia 30360-2105 Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Mon May 25, 2015 06:03 PM Quote | ReplyI have thought about the crowdfunding idea and I think we should give it a serious preliminary think through. If we can more or less agree on the outline, we could move ahead.

It is disappointing and somewhat surprising that no one has tried to fund someone with IV 3-BP before. Often with charity donors become fatigued. There is never any clear sense of a payback. However, with funding IV 3-BP everyone gains valuable knowledge of another reported patient. If people appreciate that funding the campaign is in their self-interest we might have no problem raising money. If we are successful others might imitate our efforts (which could really move things forward).

Probably one thing to start out with is that group efforts can easily bog down with internal bickering and it is often better to just try to go it alone. Hopefully, we can all work together on this: Remember if more 3-BP reports are made public everyone gains!

It will be especially important to do this outside of the artificial constraints of a clinical trial. Often with a clinical trial they are primarily interested in what happens when using mono-therapy: giving only one medication by one route of adminstration is likely not in the best interests of the patient. Any patient we supported might receive oral MG, IV 3-BP and possibly something inhaled.

Here is a basic outline that we can use as a starting point of for discussion.

Crowdfunding vehicle: Indiegogo Life, Kickstarter ?

Designated Cancer Clinic: Dayspring-- they have been the leader with 3-BP. One of the only cancer clinics that clearly state on their website that they treat with 3-BP.

Funding Goal: US $30000

Patient to fund: Serious-Terminal (3-6 month life expectancy), few if any brain mets, other medical options considered futile, (will need to consult with cancer clinic to determine what patients they would agree to treat), possibly source patient from someone on thread

Treatment: IV 3-BP, (MG, salinomycin ?), doctors discretion

Duration: Depending on funding we could provide ongoing followup.

Report Result: write up patient outcome and publish to web for funders and others

Potential Funding Support: our threads, several other cancer patient threads, wehaveacure website, general public Quote | Reply

=Anyone used 3bp (3-bromopyruvate)?= View all Alternative Treatments Discussions Post A New Discussion947 Posts | Page(s): Prev 12...92 93 94 95  Next Danielus
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RE: Anyone used 3bp (3-bromopyruvate)?
by Danielus on Mon May 25, 2015 06:16 PM Quote | ReplySounds good to me. I asked Dr. Dickens in an offline communication and he likes the idea as well.

Jcancom, since fortunately you/your family is not challenged by this health issue (as I understand), you may have more time to organise this action. Would you take care of it and delegate to us when you need help?

kcervantes point is also very important - so at least lets try to balance the discussions here in such a way that would help others on short term as well. Like sharing relevant info regarding 3BP administration, outcomes, etc. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Mon May 25, 2015 06:32 PM Quote | ReplyGreat! I am glad Dayspring is onboard.

I don't think it could have worked without them. We can consult with them regarding patient parameters, treatment, definitions of patient success and failure, bank account info, etc..

We can mostly hand off clinical care decisions to them and the patient selected. (Though I am sure we all have a few suggestions we might want to put forward (e.g. oral methylglyoxal).

I am not completely sure how we can run the campaign on behalf of the patient. Such a patient might not have much energy to devote to the site. Perhaps the patient could do the set up (or we could do it for them) and then we could be given the password to manage the campaign.

In terms of disclosing patient personal information for the campaign. We will have to be sensitive to those concerns.

More input on this idea would be great before we get started.

Yes-- it will be great to share 3-BP treatment info here on the thread. Once the crowdfunding campaign gets started we can get back to a  thread more focused on 3-BP.

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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Mon May 25, 2015 06:55 PM Quote | ReplyI just realized that Dayspring did not blink when we described the prognosis for the patient we want to send to them. Perceptive observers should find this very encouraging. The campaign will be in full public view and the clinic considers such a patient treatable!

We might this work this into our campaign narrative. It is similar to a game of cards: Dayspring was the dealer, knows what everyone has in their hand and just doubled down. Are they bluffing?

The patient would be similar to the published patients, though perhaps a step or two back in terms of severity. We would want to show that a seriously ill cancerpatient could be with IV 3-BP and experience a meaningful recovery without the confounders of complications that arose in the published reports. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterkcervantes
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RE: Anyone used 3bp (3-bromopyruvate)?
by kcervantes on Mon May 25, 2015 09:19 PM Quote | ReplyMy husband would be a perfect candidate:)  We're not far from Arizona either.  Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Mon May 25, 2015 09:49 PM Quote | ReplyOk. That is great. Are there any others on the thread that want to apply? Otherwise, we could count it down 3-2-1. Closed.

I am just a little worried that you said you were all set to start home IV 3-BP. The campaign could take some time-- possibly up to a few months. This might be a problem in terms of delaying treatment.

What is the clinical description of your husband? Dayspring seems to be willing to accept a patient with fairly extensive illness. IV 3-BP could really show us what is can do with a typical cancer patient.

I was just doing the startup for the campaign. I was  getting to the part about who the campaign was for. It might be easier for whoever wants to run the campaign to create it for themselves, though I thought it would be great if we could run it as a thread project. This would probably get somewhat complicated. Perhaps it would be easiest if we could just give you suggestions on how to word things.

I was not sure how much personal disclosure the patient would feel comfortable disclosing. It looks like most medical campaigns on Indiegogo Life do raise some money, though few if any raise up to 30K. However, there is quite a 3-BP community that could help us out.

Website is Indiegogo Life all they need is an email and password. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Mon May 25, 2015 10:18 PM Quote | ReplyIt probably would be best to leave to posters on the thread to set up their own campaigns. In that way we do not have to feel that we are choosing some over others.

Posters could help out with ideas and contacts with Dayspring and others. I think going to the wehaveacure site (3-BP) and publicizing the campaign would make a lot of sense. Right there you have an installed base of committed 3-BPers. It would be surprising if money could not be raised there.

Another idea that a campaign should probably emphasize is there have only been 2 published reports with 3-BP. Raising money for another patient is important for the entire cancer community and beyond. Patient treatment reports should be a part of the storyline for the campaign pitch. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Tue May 26, 2015 07:11 PM Quote | ReplyVery excited about the crowdfunding idea: this could really put us over the top. There are a lot of people out there who want to see 3-BP move forward but have not had a vehicle to make it happen.

It might not take long now for substantial momentum to build behind 3-BP, if others take advantage of crowdfundraising and the treatment results are strong. I have said before that if terminal cancer patients were enrolled into a trial (or with crowdfunding) we could have an answer within weeks. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Wed May 27, 2015 09:06 PM Quote | ReplyHave the rules for the forum changed?

I just sent a private message and I was told it would be reviewed! Am I the only one here who is a little creeped out that this forum will now read private messages and decide whether each private message should be sent? Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Wed May 27, 2015 09:20 PM Quote | ReplyIt is very strange. You can post to the thread without review, though you cannot private message without review!

For the past few days I have been looking into what routes are used to synthesize 3-BP. [Click below on url and then on view details for further details and journal references.] I have found it interesting thinking about the 5 different routes of synthesis.

Consider that the chemical suppliers would likely try the cheapest route, though this would not necessarily be the safest, considering the other products generated during the reaction. Consider the synthesis route that uses water: this generates a contaminant called 3,3 dibromo-2-oxopropanoic acid. It sounds scary.The 1-diazonio one looks interesting. The ethyl-bromopyruvate could be another cancer fighter (It is similar to 3BrOP.).

I have also thought that it would be pretty neat if you could take your 3-BP to a chemical "polisher" that could help remove some of the contaminants. It is quite possible that the chemical suppliers do not make any particular effort to remove contaminants. Several methods spring to my mind.

For example: the density of 3-BP is about 2.5. It should sink. In some of the reactions, the contaminants have a       density of less tahn 1. They should float on water. Simply putting the 3-BP mixture and filtering the top layer would help purify it. I have read that a user of 3-BP did just that as there was a yellow substance floating on the top! Other purifications could be done include heating it etc..

http://www.molbase.com/en/synthesis_1113-59-3-moldata-8403.h

One advantage of going to a recognized cancer clinic for 3-BP would be that they would have worked all this through. They would know which synthesis route was best (though probably not the cheapest) and have polished the 3-BP so unknown contaminants were not floating on top. Their 3-BP might approach pharmaceutical grade.

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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Wed May 27, 2015 09:37 PM Quote | ReplyIt is very strange. You can post to the thread without review, though you cannot private message without review!

For the past few days I have been looking into what routes are used to synthesize 3-BP. [Click below on url and then on view details for further details and journal references.] I have found it interesting thinking about the 5 different routes of synthesis.

Consider that the chemical suppliers would likely try the cheapest route, though this would not necessarily be the safest, considering the other products generated during the reaction. Consider the synthesis route that uses water: this generates a contaminant called 3,3 dibromo-2-oxopropanoic acid. It sounds scary.The 1-diazonio one looks interesting. The ethyl-bromopyruvate could be another cancer fighter (It is similar to 3BrOP.).

I have also thought that it would be pretty neat if you could take your 3-BP to a chemical "polisher" that could help remove some of the contaminants. It is quite possible that the chemical suppliers do not make any particular effort to remove contaminants. Several methods spring to my mind.

For example: the density of 3-BP is about 2.5. It should sink. In some of the reactions, the contaminants have a       density of less tahn 1. They should float on water. Simply putting the 3-BP mixture and filtering the top layer would help purify it. I have read that a user of 3-BP did just that as there was a yellow substance floating on the top! Other purifications could be done include heating it etc..

http://www.molbase.com/en/synthesis_1113-59-3-moldata-8403.h

One advantage of going to a recognized cancer clinic for 3-BP would be that they would have worked all this through. They would know which synthesis route was best (though probably not the cheapest) and have polished the 3-BP so unknown contaminants were not floating on top. Their 3-BP might approach pharmaceutical grade.

Quote | Reply

=Anyone used 3bp (3-bromopyruvate)?= View all Alternative Treatments Discussions Post A New Discussion947 Posts | Page(s): Prev 12...93 94 95 Jcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Thu May 28, 2015 12:16 AM Quote | ReplyThe thread and private messaging went down for a few hours there. We should all agree to move the conversation to

http://3bromopyruvate.wikia.com/wiki/Board:New_on_3-bromopyr

if this forum is being shut down. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Thu May 28, 2015 12:21 AM Quote | ReplyFor the past few days I have been looking into what routes are used to synthesize 3-BP. [Click below on url and then on view details for further details and journal references.] I have found it interesting thinking about the 5 different routes of synthesis.

Chemical suppliers would likely try the cheapest route, though this would not necessarily be the safest for patients, considering the other products generated during the reaction. Consider the synthesis route that uses water: this generates a contaminant called 3,3 dibromo-2-oxopropanoic acid. It sounds scary.The 1-diazonio one looks interesting. Ethyl-bromopyruvate could be another cancer fighter (It is similar to 3BrOP.).

I have also thought that it would be pretty neat if you could take your 3-BP to a chemical "polisher" that would remove some of the contaminants. It is quite possible that the chemical suppliers do not make any particular effort to remove contaminants. Several methods spring to my mind.

For example: the density of 3-BP is about 2.5. It should sink in water. In some of the reactions, the contaminants have a  density of less than 1. They should float on water. Simply putting the 3-BP mixture and filtering the top layer would help purify it. I have read that a user of 3-BP did just that as there was a yellow substance floating on the top! Other purifications could be done include heating it etc..

http://www.molbase.com/en/synthesis_1113-59-3-moldata-8403.h

One advantage of going to a recognized cancer clinic for 3-BP would be that they would have worked all this through. They would know which synthesis route was best (though probably not the cheapest) and have polished the 3-BP so unknown contaminants were not floating on top. Their 3-BP might approach pharmaceutical grade. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterGenelle
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RE: Anyone used 3bp (3-bromopyruvate)?
by Genelle on Thu May 28, 2015 12:58 AM Quote | ReplyI think your message was too large. That happened to me when I tried to send you a large message once Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Thu May 28, 2015 12:37 PM Quote | ReplyFor the past few days I have been looking into what routes are used to synthesize 3-BP. [Click below on url and then on view details for further details and journal references.] I have found it interesting thinking about the 5 different routes of synthesis.

Chemical suppliers would likely try the cheapest route, though this would not necessarily be the safest for patients, considering the other products generated during the reaction. Consider the synthesis route that uses water: this generates a contaminant called 3,3 dibromo-2-oxopropanoic acid. It sounds scary.The 1-diazonio one looks interesting. Ethyl-bromopyruvate could be another cancer fighter (It is similar to 3BrOP.).

I have also thought that it would be pretty neat if you could take your 3-BP to a chemical "polisher" that would remove some of the contaminants. It is quite possible that the chemical suppliers do not make any particular effort to remove contaminants. Several methods spring to my mind.

For example: the density of 3-BP is about 2.5. It should sink in water. In some of the reactions, the contaminants have a  density of less than 1. They should float on water. Simply putting the 3-BP mixture and filtering the top layer would help purify it. I have read that a user of 3-BP did just that as there was a yellow substance floating on the top! Other purifications could be done include heating it etc..

http://www.molbase.com/en/synthesis_1113-59-3-moldata-8403.h

One advantage of going to a recognized cancer clinic for 3-BP would be that they would have worked all this through. They would know which synthesis route was best (though probably not the cheapest) and have polished the 3-BP so unknown contaminants were not floating on top. Their 3-BP might approach pharmaceutical grade. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Thu May 28, 2015 12:39 PM Quote | ReplyFor the past few days I have been looking into what routes are used to synthesize 3-BP. [Click below on url and then on view details for further details and journal references.] I have found it interesting thinking about the 5 different routes of synthesis.

Chemical suppliers would likely try the cheapest route, though this would not necessarily be the safest for patients, considering the other products generated during the reaction. Consider the synthesis route that uses water: this generates a contaminant called 3,3 dibromo-2-oxopropanoic acid. It sounds scary.The 1-diazonio one looks interesting. Ethyl-bromopyruvate could be another cancer fighter (It is similar to 3BrOP.).

I have also thought that it would be pretty neat if you could take your 3-BP to a chemical "polisher" that would remove some of the contaminants. It is quite possible that the chemical suppliers do not make any particular effort to remove contaminants. Several methods spring to my mind.

For example: the density of 3-BP is about 2.5. It should sink in water. In some of the reactions, the contaminants have a  density of less than 1. They should float on water. Simply putting the 3-BP mixture and filtering the top layer would help purify it. I have read that a user of 3-BP did just that as there was a yellow substance floating on the top! Other purifications could be done include heating it etc..

http://www.molbase.com/en/synthesis_1113-59-3-moldata-8403.h

One advantage of going to a recognized cancer clinic for 3-BP would be that they would have worked all this through. They would know which synthesis route was best (though probably not the cheapest) and have polished the 3-BP so unknown contaminants were not floating on top. Their 3-BP might approach pharmaceutical grade. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twitterJcancom
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RE: Anyone used 3bp (3-bromopyruvate)?
by Jcancom on Thu May 28, 2015 12:48 PM Quote | ReplyFor the past few days I have been looking into what routes are used to synthesize 3-BP. [Click below on url and then on view details for further details and journal references.] I have found it interesting thinking about the 5 different routes of synthesis.

Chemical suppliers would likely try the cheapest route, though this would not necessarily be the safest for patients, considering the other products generated during the reaction. Consider the synthesis route that uses water: this generates a contaminant called 3,3 dibromo-2-oxopropanoic acid. It sounds scary.The 1-diazonio one looks interesting. Ethyl-bromopyruvate could be another cancer fighter (It is similar to 3BrOP.).

I have also thought that it would be pretty neat if you could take your 3-BP to a chemical "polisher" that would remove some of the contaminants. It is quite possible that the chemical suppliers do not make any particular effort to remove contaminants. Several methods spring to my mind.

For example: the density of 3-BP is about 2.5. It should sink in water. In some of the reactions, the contaminants have a  density of less than 1. They should float on water. Simply putting the 3-BP mixture and filtering the top layer would help purify it. I have read that a user of 3-BP did just that as there was a yellow substance floating on the top! Other purifications could be done include heating it etc..

http://www.molbase.com/en/synthesis_1113-59-3-moldata-8403.h

One advantage of going to a recognized cancer clinic for 3-BP would be that they would have worked all this through. They would know which synthesis route was best (though probably not the cheapest) and have polished the 3-BP so unknown contaminants were not floating on top. Their 3-BP might approach pharmaceutical grade. Quote | Reply<span class="at4-icon aticon-compact" style="background-color: rgb(252, 109, 76);">More Sharing Services Share <span class="at4-icon aticon-email" style="background-color: rgb(115, 138, 141);">Share on email <span class="at4-icon aticon-facebook" style="background-color: rgb(48, 88, 145);">Share on facebook <span class="at4-icon aticon-twitter" style="background-color: rgb(44, 168, 210);">Share on twittermahkcots
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RE: Anyone used 3bp (3-bromopyruvate)?
by mahkcots on Thu May 28, 2015 04:28 PM Quote | ReplyThese are great results. Could anyone provide me a list of all of the centers and/ or doctors who have access to 3bp and are willing to use it. I am currently aware of the Dayspring Cancer Center in Arizona and apparently Dr. Munoz as well. The Dayspring website says it is one of only a few centers with access to 3bp. I was wondering what the others were. Quote | Reply